The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Neuroactivation studies using Functional Brain MRI

기능적 자기공명영상을 이용한 뇌활성화 연구

  • Chung, Kyung-Ho (Department of Diagnostic Radiology, Chonbuk National University Medical School)
  • 정경호 (전북대학교 의과대학 진단방사선과)
  • Published : 2003.02.28
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Abstract

Functional MRI (fMRI) provides an indirect mapping of cerebral activity, based on the detection of the local blood flow and oxygenation changes following neuronal activity (Blood Oxygenation Level Dependent). fMRI allows us to study noninvasively the normal and pathological aspects of functional cortical organization. Each fMRI study compares two different states of activity. Echo-Planar Imaging is the technique that makes it possible to study the whole brain at a rapid pace. Activation maps are calculated from a statistical analysis of the local signal changes. fMRI is now becoming an essential tool in the neurofunctional evaluation of normal volunteers and many neurological patients as well as the reference method to image normal or pathologic functional brain organization.

Keywords

References

  1. Yoshiura T, Wu O, Sorensen AG. Advanced MR techniques: diffusion MR imaging, perfusion MR imaging, and spectroscopy. Neuroimaging Clin N Am 1999;9:439-53
  2. Kim YJ, Chang KH, Song IC, Kim HD, Seong SO, Kim YH, et al. Brain abscess and necrotic or cystic brain tumor: discrimination with signal intensity on diffusion-weighted MR imaging. Am J Roentgenol 1998;171:1487-90
  3. Shin JH, Lee HK, Kwun BD, Kim JS, Kang W, Choi CG, et al. Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. Am J Roentgenol 2002;179:783-9
  4. Bitzer M, Klose U, Geist-Barth B, Nagele T, Schick F, Morgalla M, et al. Alterations in diffusion and perfusion in the pathogenesis of peritumoral brain edema in meningiomas. Eur Radiol 2002;12:2062-76
  5. Ishimaru H, Morikawa M, Iwanaga S, Kaminogo M, Oehi M, Hayashi K. Differentiation between high-grade glioma and metastatic brain tumor nsing single-voxel proton MR spectroscopy. Eur Radiol 2001;11:1784-91
  6. Lejeune H, Maquet P, Bonnet M, Casini L, Ferrara A, Macar F, et al. The basic pattern of activation in motor and sensory temporal tasks: positron emission tomography data. Neurosci Lett 1997;235:21-4
  7. Ramsey NF, Kirkby BS, Van Gelderen P, Berman KF, Duyn JH, Frank JA, et al. Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with H2(l5)0 PET rCBF. J Cereb Blood Flow Metab 1996;16:755-64
  8. Stern E, Silbersweig DA. Advances in functional neuroimaging methodology for the study of brain systems underlying human neuropsychological function and dysfunction. J Clin Exp Neuropsychol 2001;23:3-18
  9. Engelien A, Stern E, Silbersweig D. Functional neuroimaging of human central auditory processing in normal subjects and patients with neurological and neuropsychiatric disorders. J Clin Exp Neuropsychol 2001;23:94-120
  10. Connelly A, Jackson GD, Frackowiak RS, Belliveau JW, Vargha-Khadem F, Gadian DG. Functional mapping of activated human primary cortex with a clinical MR imaging system. Radiology 1993;188:125-30
  11. Frahm J, Merboldt K, Hanicke W. Functional MRI of human brain activation at high spatial resolution. Magn Reson Med 1993;29:139-44
  12. Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 1986;83:1140-4
  13. Phelps ME, Kuhl DE, Mazziotta JC. Metabolic mapping of the brain's response to visual stimulation: studies in humans. Science 1981;211:1445-8
  14. Rao SM, Binder JR, Hammeke TA, Bandettini PA, Bobholz JA, Frost JA, et al. Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging. Neurology 1995;45:919-24
  15. Hammeke TA, Yetkin FZ, Mueller WM, Morris GL, Haughton VM, Rao SM, et al. Functional magnetic resonance imaging of somatosensory stimulation. Neurosurgery 1994;35:677-81
  16. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, et al. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Nat! Acad Sci USA 1992;89:5951-5
  17. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 1993;64:803-12
  18. Duyn JH, Moonen CT, van Yperen GH, de Boer RW, Luyten PR. Inflow versus deoxyhemoglobin effects in BOLD functional MRI using gradient echoes at 1.5 T. NMR Biomed 1994;7:83-8
  19. Bandettini PA, Wong EC, Jesmanowicz A, Hinks RS, Hyde JS. Spin-echo and gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1.5 T. NMR Biomed 1994;7: 12-20
  20. Hathout GM, Gambhir SS, Gopi RK, Kirlew KA, Choi Y, So G, et al. A quantitative physiologic model of blood oxygenation for functional magnetic resonance imaging. Invest Radiol 1995;30:669-82
  21. Turner R, Jezzard P, Wen H, Kwong KK, Le Bihan D, Zeffiro T, et al. Functional mapping of the human visual cortex at 4 and 1.5 tesla using deoxygenation contrast EPI. Magn Reson Med 1993;29:277-9
  22. Thompson RM, Jack CR Jr, Butts K, Hanson DP, Riederer SJ, Elunan RL, et al. Imaging of cerebral activation at 1.5 T: optimizing a technique for conventional hardware. Radiology 1994;190:873-7
  23. Kim JR, Shin T, Kim JS, Kim HJ, Chung SH. MR imaging of cerebral activation performed with a gradient-echo technique at 1.5T: sources of activation signals. Am J Roentgenol 1996;167:1277-81
  24. Haacke EM, Hopkins A, Lai S, Buckley P, Friedman L, Meltzer H, et al. 2D and 3D high resolution gradient echo functional imaging of the brain: venous contributions to signal in motor cortex studies. NMR Biomed 1994;7:54-62
  25. Jack CR Jr, Thompson RM, Butts RK, Sharbrough FW, Kelly PJ, Hanson DP, et al. Sensory motor cortex: correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology 1994;190:85-92
  26. Yousry TA, Schmid UD, Jassoy AG, Schmidt D, Eisner WE, Reulen HJ, et al. Topography of the cortical motor hand area: prospective study with functional MR imaging and direct motor mapping at surgery. Radiology 1995;195:23-9
  27. Yetkin FZ, Mueller WM, Morris GL, McAuliffe TL, Ulmer JL, Cox RW, et al. Functional MR activation correlated with intraoperative cortical mapping. Am J Neuroradiol 1997;18:1311-5
  28. Gomiscek G, Beisteiner R, Hittmair K, Mueller E, Moser E. A possible role of in-flow effects in functional MR imaging. Mag Reson Materials in Phys, Bio, Med 1993;1:109-13
  29. Mattay VS, Frank JA, Santha AK, Pekar JJ, Duyn JH, McLaughlin AC, et al. Whole-brain functional mapping with isotropic MR imaging. Radiology 1996;201:399-404
  30. Menon RS, Thomas CG, Gati JS. Investigation of BOLD contrast in fMRI using multi-shot EPI. NMR Biomed 1997;10:179-82
  31. Howseman AM, Bowtell RW. Functional magnetic resonance imaging: imaging techniques and contrast mechanisms. Philos Trans R Soc Lond B Bioi Sci 1999;354:1179-94
  32. Howseman AM, Grootoonk S, Porter DA, Ramdeen J, Holmes AP, Turner R. The effect of slice order and thickness on fMRI activation data using multislice echo-planar imaging. Neuroimage 1999;9:363-76
  33. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 1995;2:189-210
  34. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 1996;29:162-73
  35. Strupp JP. Stimulate: a GUI based fMRI analysis software package. Neuroimage 1996;3:S607
  36. Baudendistel K, Schad LR, Friedlinger M, Wenz F, Schroder J, Lorenz WJ. Postprocessing of functional MRI data of motor cortex stimulation measured with a standard 1.5 T imager. Magn Reson Imaging 1995;13:701-7
  37. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS. Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 1993;30:161-73
  38. Ardekani BA, Kanno I. Statistical methods for detecting activated regions in functional MRI of the brain. Magn Reson Imaging 1998;16:1217-25
  39. Kwong KK, Belliveau JW, Chesler DA, Goldberg JE, Weisskoff RM, Poncelet BP, et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 1992;89:5675-9
  40. Blamire AM, Ogawa S, Ugurbil K, Rothman D, McCarthy G, Ellermann JM, et al. Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci USA 1992;89:11069-73
  41. Rao SM, Binder JR, Bandettini PA, Hammeke TA, Yetkin FZ, Jesmanowicz A. Functional magnetic resonance imaging of complex human movements. Neurology 1993;43:2311-8
  42. Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, et al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 1996;46:978-84
  43. Yetkin FZ, Papke RA, Mark LP, Daniels DL, Mueller WM, Haughton VM. Location of the sensorimotor cortex: functional and conventional MR compared. Am J Neuraradiol 1995;16:2109-13
  44. Chung GH, Han YM, Kim CS. Functional MRI of the supplementary motor area: comparison of motor and sensory tasks. J Comput Assist Tomogr 2000;24:521-5
  45. Talairach J, Tiurnoux P. Co-Planar stereotactic atlas of the human brain. 1$^{st}$ ed. New York: Thieme Medical Publishers; 1988. p.1-11
  46. Urbach H, Von Oertzen J, Klemm E, Koenig R, Linke DB, Kurthen M, et al. Selective middle cerebral artery Wada tests as a part of presurgical evaluation in patients with drug-resistant epilepsies. Epilepsia 2002;43:1217-23
  47. Bahn MM, Lin W, Silbergeld DL, Miller JW, Kuppusamy K, Cook RJ, et al. Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation. Am J Roentgenol 1997;169:575-9
  48. Wada J, Rasmussen T. Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance. Experimental and clinical observations. J Neurosurg 1960;17:266-82
  49. Yetkin O, Zerrln Yetkin F, Haughton VM, Cox RW. Use of functional MR to map language in multilingual volunteers. Am J Neuroradiol 1996;17: 473-7
  50. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry 1999;45:1128-37
  51. D'Esposito M. Functional neuroimaging of cognition. Semin Neural 2000;20:487-98
  52. Fletcher PC, Henson RN. Frontal lobes and human memory: insights from functional neuroimaging. Brain 2001;124:849-81
  53. Kim B, Boes JL, Bland PH, Chenevert TL, Meyer CR. Motion correction in fMRI via registration of individual slices into an anatomical volume. Magri Reson Med 1999;41:964-72