Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Hepatoprotective Effect of the Methanol Fraction of Chinese Cabbage on Liver Injury in Rats Treated by bromobenzene

Chinese Cabbage 잎과 뿌리가 메탄올층의 Bromobenzene 간손상에 대한 보호효과

  • Lee Hyo Jung (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Kwan Hyun (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee Eun Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Choi Jong Won (College of Pharmacy, Kyongsung University) ;
  • Kang Kyung Sun (Department of Veterinary Public Health, College of Veterianry Medicine, Seoul university) ;
  • Yoon Byong Su (Department of Biology, Kyonggi University) ;
  • Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학 대학원) ;
  • 김관현 (경희대학교 동서의학 대학원) ;
  • 이은옥 (경희대학교 동서의학 대학원) ;
  • 최종원 (경성대학교 약학과) ;
  • 강경선 (서울대학교 수의과대학) ;
  • 윤병수 (경기대학교 생물학과) ;
  • 김성훈 (경희대학교 동서의학 대학원)
  • Published : 2003.10.01
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Abstract

Chinese cabbage is a vegetable of Cruciferous family. It was usually consumed as Kimchi. It was known to have amount of vitamin c. Recently the trend for the development of functional food combined with oriental herbs. For this aim the study was performed to evaluate the hepatoprotective effect via antioxidant activity of leaf and root of Sanchon Chinese cabbage(Brassica campetris L.) comparatively. The methanol extracts of Chinese cabbage were tested for investigating the effects on the formation of lipid peroxide and the activities of free radical generating enzyme in vitro in bromobenzene-treated rats. The methanol extracts of chinese cabbage reduced bromobenzene-induced hepatic lipid peroxidation and inhibited the activity of xanthine oxidase. The methanol extracts of chinese cabbage did not activate amionopyrine N-demethylase, aniline hydroxylase and glutathione S-transferase. Epoxide hydrolase activity was decreased by bromobenzene, which was restored by pretreatment of the methanol extracts of chinese cabbage. The results suggest that the methanol extracts of Chinese cabbage is reduced by enhancing the activity of epoxide hydrolase.

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References

  1. 방약합편 염태환(역편)
  2. Int J Cancer. v.102 no.3 Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell Hu H.;Ahn N.S.;Yang X.;Lee Y.S.;Kang K.S.
  3. Cancer Res. v.15;56 no.4 Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats F. L. Chung;G. Kelloff;V. Steele;B. Pittman;E. Pittman;D. Jiao;J. Rigotty;C. I.;Choi, A;Rivenson.
  4. Carcinogenesis. v.17 no.4 Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate T. J. Smith;Z. Guo;F. P. Guengerich;C. S. Yang.
  5. Biofactors. v.13 no.1-4 Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi Y. Morimitsu;K. Hayashi;Y. Nakagawa;F. Horio;K. Uchida;T. Osawa.
  6. J Agric Food Chem. v.48 no.2 Separation and purification of anthocyanins by high-speed countercurrent chromatography and screening for antioxidant activity A. Degenhardt;H. Knapp;P. Winterhalter.
  7. Free Radic Res. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition A. R. Proteggente;A. S. Pannala;G. Paganga;L. Van Buren;E. Wagner;S. Wiseman;F. Van De Put;C. Dacombe;C. A. Rice-Evans.
  8. Free Radic Res. v.25 no.1 Are whole extracts and purified glucosinolates from cruciferous vegetables antioxidants? Plumb GW;Lambert N;Chambers SJ;Wanigatunga S;Heaney RK;Plumb JA;Aruoma OI;Halliwell B;Miller NJ;Williamson G.
  9. Nature v.26 Antioxidant determinations by the use of a stable free radical Blois, MS.
  10. Kor. J. Pharmacogn. v.28 no.4 Hepatoprotective effect of extracts and phenolic compound from marine algae in bromobenzene-treated Rats Jong-Cheol Park;Jae-Sue Choi;Sang-Ho Song;Myeong-Rak Choi;Kwang-Young Kim;Jong-won Choi.
  11. Korean J Nutrition v.27 no.10 Effects of korean Green Tea, Oolong Tea and Black Tea Beverage on the antioxidative detoxification in Rat Poisoned with Cadmium Yeon-Hee Yoon;Soon-Jae Rhee
  12. Kor. J. Pharmacogn. v.23 no.2 The effect of Scoparone on the Hepatic Bromobenzene metabolizing enzyme system in Rats Eun Ju Kim;Chung Kyu Lee;Jong Won Choi
  13. Journal of Ethnopharmacology v.85 Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea Kyoung Soon Kim;Sang hyun Lee;Yeon Sil Lee;Sang Hoon Jung;Youmie Park;Kuk Hyun Shin;Bak-Kwang Kim
  14. Int J Cancer v.97 no.4 Dietary factors and gastric cancer in Korea: a case-control study Kim HJ;Chang WK;Kim MK;Lee SS;Choi
  15. Anal. Biochem. v.95 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Ohkawa,H.;Ohishi, N.;Yaki, K.
  16. J. Biol. Chem. v.244 The reaction of rat liver xanthine oxidase: Conversion in vitro of the enzyme activity from dehydrogenase (Type D) to oxidase (Type O) Stripe. F.;Della Corte. E.
  17. J. Biol. Chem. v.55 The colorimetric estimarion of formaldehyde by means of the hentisch reaction Nash. T.
  18. Biochem. Pharmacol. v.31 Multiple drug metabolism: p-Nitoroanisole reversal of acetone enhanced aniline hydroxylation Bidlack. W. R.;Lowry. G. L.
  19. J. Biol. Chem. v.249 The first step in mercapturate acid formation Habig. W. H.;Pabist. M. J.;Jakoby. W. B.
  20. Biochem. Pharmacol. v.31 Spectrophotometric assay for mammalian cytosolic epoxide hydrolase using trans-stilbeneoxide as the substrate Hasegawa. L. S.;Hammock. B. D.
  21. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry. O. H.;Rodebrough. N. J.;Farr. A. L.;Randall. R. J.
  22. Environmental Health Perspectives no.Sup. 5 Lipid Peroxidation Products and Antioxidants in Human Disease Francisco J. Romero;Francisco Bosch-Morell;Mar a J. Romero;Enrique J. Jareo; Bel n Romero;Nuria Mar n;Joaquin Rom
  23. Biochem. Pharmacol. v.34 Inhibition of purifed rat liver glutathion S-transferase isozymes by diuretic drugs J T Ahokas;F A Nicholas;P J Ravenschoft;B T Emmerson