Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Particle Size of Aerosol from 0.25% Cadmium Chloride Nebulizing Solution for Inhalation Toxicology Study

흡입독성 연구에 이용될 0.25% 염화카드뮴 네뷸라이징 용액 에어로졸의 입경

  • Jeung Jae Yeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2003.10.01
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Abstract

The modified engineering methodology and the modified electronic circuit in classical ultrasonic principles were applied to ultrasonic aerosol nebulizer for inhalation toxicology study of cadmium aerosol. 1532.96ppm Cd nebulizing solution was used to generate cadmium aerosol for particle size analysis with the modifying source and inlet temperatures. The results of particle size analysis for cadmium aerosol were as following. The highest particle counting for source temperature 20℃ was 399.75 × 10² in inlet temperature 100℃ and particle diameter 0.75㎛. The highest particle counting for source temperature 50℃ was 399.70 × 10² in inlet temperature 50℃ and particle diameter 0.75㎛. The highest particle counting for source temperature 70℃ was 411.14 × 10² in inlet temperature 100℃ and particle diameter 0.75㎛. The ranges of geometric mean diameter were 0.74-0.79㎛ in source temperature 20℃, 0.65-0.72㎛ in source temperature 50℃, and 0.65-0.80㎛ in source temperature 70℃. The smallest geometric mean diameter was 0.65㎛ in source temperature 50, 70℃ and inlet temperature 20, 50℃, and the largest geometric mean diameter was 0.80㎛ in source temperature 70℃ and inlet temperature 100℃. The ranges of geometric standard deviation were 1.71-1.80 in source temperature 20℃, 1.27-1.61 in source temperature 50℃, and 1.27-2.29 in source temperature 70℃. The lowest geometric standard deviation was 1.27 in source temperature 50, 70℃ and inlet temperature 20, 50℃, and the highest geometric standard deviation was 2.29 in source temperature 70℃ and inlet temperature 100℃. Generated aerosol for cadmium inhalation toxicology study was polydisperse aerosol with the above geometric standard deviation 1.2. The ranges of mass median diameter(MMD) were 1.75-2.25㎛ in source temperature 20℃, 1.27-1.61㎛ in source temperature 50℃, and 1.27-2.29㎛ in source temperature 70℃. The smallest MMD was 1.27㎛ in source temperature 50, 70℃ and inlet temperature 20, 50℃, and the largest MMD was 2.29㎛ in source temperature 70℃ and inlet temperature 100℃. Cadmium chloride concentration in nebulizing solution affected the particle size and distribution of cadium aerosol in air. MMO for inhalation toxicology testing in OECD and EU is less than 3㎛ and EPA guidance is less than 4㎛. In our results, in source temperatures of 20, 50, 70℃, and inlet temperatures of 20, 50, 100, 150, 200, 250℃ were conformed to the those guidance.

Keywords

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