Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Pear Phenolic Compound on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertophy in Hypertensive RAT Induced by 2K1C

배 추출 Phenolic compound 투여가 흰쥐의 혈압 변화, 혈장 Renin, ANP 및 Cardiac hypertrophy에 미치는 영향

  • Na Chang Su (Department of Oriental Medicine Dongshin University) ;
  • Yun Dae Hwan (Department of Oriental Medicine Dongshin University) ;
  • Choi Dong Hee (Department of Oriental Medicine Dongshin University) ;
  • Kim Jeong sang (Department of Oriental Medicine Dongshin University) ;
  • Jo Chun Hwa (Department of Medicine Chonbuk National University) ;
  • Eun Jong Bang (Department of food science and technology Chonnam National University)
  • Published : 2003.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.

Keywords

References

  1. 本草綱目通釋 陳貴延
  2. J Nutr v.124 no.6 Prickly pear(Opuntia sp.) pectin alters hepatic cholesterol metabo¬lism without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet. Fernandez ML;Lin EC;Trejo A;McNamara DJ.
  3. J Ethnopharmacol v.55 no.1 A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. Trejo-Gonzalez A.;Gabriel-Ortiz G.;Puebla-Perez A. M.;Huizar-Contreras M. D.;Munguia-Mazariegos M. R.;Mejia¬Arreguin S;Calva E. https://doi.org/10.1016/S0378-8741(96)01467-5
  4. Pediatrics v.105 no.1 Carbohydrate absorption from fruit juices in infants. Lifschitz CH. https://doi.org/10.1542/peds.105.1.e4
  5. J Clin Gastroenterol v.30 no.2 Effect of gastric myoelectric activity on carbohydrate absorption of fruit juice in children. Moukarzel AA;Sabri MT. https://doi.org/10.1097/00004836-200003000-00002
  6. 천연물화학연구법 우원식
  7. Appl Environ Microbiol v.32 no.6 Virus inactivation by grapes and wines. Konowalchuk J.;Speirs J. I.
  8. Chem Pharm Bull v.37 no.11 Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and gIisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase. Hatano T;Yasuhara T;Fukuda T;Noro T;Okuda T. https://doi.org/10.1248/cpb.37.3005
  9. Life Sci v.38 no.15 Antihypertensive substance in seeds of Areca catechu L. Inokuchi J;Okabe H;Yamauchi T;Nagamatsu A;Nonaka G;Nishioka I. https://doi.org/10.1016/0024-3205(86)90470-4
  10. Chem Pharm Bull v.31 no.7 Mechanism of the blood urea nitrogen-decreasing activity of rhatannin from Rhei Rhizoma in the rat. I. 10. Shibutani S;Nagasawa T;Oura H;Nonaka G;Nishioka I. https://doi.org/10.1248/cpb.31.2378
  11. Chem Pharm Bull v.33 no.1 Inhibitors of angiotensin-converting enzyme in crude drugs. II. Inokuchi J;Okabe H;Yamauchi T;Nagamatsu A;Nonaka G;Nishioka I. https://doi.org/10.1248/cpb.33.264
  12. Planta Med v.55 no.2 Ellagitannins as active constituents of medicinal plants. Okuda T;Yoshida T;Hatano T. https://doi.org/10.1055/s-2006-961902
  13. 변증시치임상요강 유지윤
  14. 변증진단학 박영배
  15. 침구학회지 v.13 no.1 약침이 자발성 고혈압 백서의 혈압에 미치는 영향 이호섭
  16. 실용중서단의결합진단치료학 상 진공연
  17. 한방임상학 채인식
  18. 혜화의학 v.11 고혈압 치료에 대한 치풍홯혈탕의 임상적 보고 김종화;변일
  19. 대한맥관외관학회지 v.11 no.2 신혈관성 고혈압 정석인;최상용;황정응
  20. 전북의대논문집 v.10 no.4 신성 고혈압 백서에서 요중 Renin활성도와 혈장 Renin활성도의 상관관계에 대하여 심용식;전찰렬;조경우;김산호
  21. 殷史 生理學 김정진
  22. 인체의 생리 김우겸
  23. 내과학(상) 이문호
  24. clin. and exper Hypertension v.18 no.3;4 Immediate early genes in blood pressure regulation J. B. Minson;L. F. Arnolda;I. J. Llewellyn-Smith;P. M. Pilowsky;S. Suzuki;J.P.Chalmers. https://doi.org/10.3109/10641969609088963
  25. Virology v.116 Identification of a 39,000 dalton protein In cells transformed by the FBJ murine osteosarcoma virus. Curran T;Teich NM. https://doi.org/10.1016/0042-6822(82)90415-9
  26. 대한신장학회지 v.20 no.3 ANP는 과연 체액 불균형 보상기전의 하나인가? 이종은
  27. 대한내분비학회지 v.2 no.2 갑상선 기능 이상에 따른 혈장 ANP의 변화. 서관식;성상규;이범유;박원;김종순
  28. Molecular Neurobiology. Fos-Jun and primary genomic response in the nervous system, Possible physiological role and pathophysiological significance. Doucet SP;Squinto SP;Bazan NG