Journal of Acupuncture Research
- 제20권4호
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- Pages.93-101
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- 2003
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
신문혈(神門穴) 침자극(鍼刺戟)이 모성분리(母性分離) 스트레스로 야기된 섭식(攝食) 장애(障碍)와 시상하부 neuropeptide Y 발현에 미치는 영향
The effect of HT7 acupuncturing on the food intake and hypothalamic neuropeptide Y expression changed by maternal separation in rat pups
-
박히준
(경희대학교 한의과대학 경혈학교실)
;
-
류연희
(경희대학교 한의과대학 경혈학교실)
;
- 홍미숙 (경희대학교 의과대학 약리학교실) ;
- 김승태 (경희대학교 한의과대학 경혈학교실) ;
-
임사비나
(경희대학교 한의과대학 경혈학교실)
-
Park, Hi-joon
(Department of Meridian and Acupoint, College of Oriental Medicine, Kyung-Hee University)
;
-
Ryu, Yeon-hee
(Department of Meridian and Acupoint, College of Oriental Medicine, Kyung-Hee University)
;
- Hong, Mee-suk (Department of Pharmacology, College of Medicine, Kyung-Hee University) ;
- Kim, Seung-tae (Department of Meridian and Acupoint, College of Oriental Medicine, Kyung-Hee University) ;
-
Lim, Sabina
(Department of Meridian and Acupoint, College of Oriental Medicine, Kyung-Hee University)
- 투고 : 2003.05.17
- 심사 : 2003.07.12
- 발행 : 2003.08.20
초록
Objective: The purpose of this study is to find out the effect of acupuncture at HT7 (Shinmun) on the feeding behavior and hypothalamic neuropeptide Y(NPY) expression in the maternally separated rat pups. Methods: To show the effect of acupuncture, we performed maternal separation(MS) for 7 days beginning on postnatal day 14, and observed body weight, food intake, and NPY immunoreactivity in the paraventricular nucleus (PVN) of hypothalamus after acupuncturing at HT7, the end of the transverse crease of the ulnar wrist of the forepaw. Results: MS induced a significant decreases in body weight and food intake, while acupuncture treatment at acupoint HT7 showed much more improvement in those evaluations. NPY-immunoreactivity in area PVN were decreased in the MS group, but significantly increased in the HT7 group. Conclusions: These findings suggest that acupuncture has an effect on the feeding disorders caused by MS, possibly by modulating NPY expression in the PVN.