Journal of Acupuncture Research

  • 제20권4호
  • /
  • Pages.209-219
  • /
  • 2003
  • /
  • 2586-288X(pISSN)
  • /
  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지

호도약침액(胡桃藥鍼液)의 유리기(遊離基) 소거(消去)와 항산화(抗酸化) 효과(效果)에 대한 실험적(實驗的) 연구(硏究)

Radical Scavenging and Antioxidant Effects of Juglandis Semen Extract(JSE)

  • 김철홍 (동의대학교 한의과대학 침구경혈학 교실) ;
  • 윤현민 (동의대학교 한의과대학 침구경혈학 교실) ;
  • 장경전 (동의대학교 한의과대학 침구경혈학 교실) ;
  • 송춘호 (동의대학교 한의과대학 침구경혈학 교실) ;
  • 안창범 (동의대학교 한의과대학 침구경혈학 교실)
  • Kim, Cheol-hong (Department of Acupuncture & Moxibustion College of Oriental Medicine, Dong-Eui University) ;
  • Youn, Hyoun-min (Department of Acupuncture & Moxibustion College of Oriental Medicine, Dong-Eui University) ;
  • Jang, Kyung-jeon (Department of Acupuncture & Moxibustion College of Oriental Medicine, Dong-Eui University) ;
  • Song, Choon-ho (Department of Acupuncture & Moxibustion College of Oriental Medicine, Dong-Eui University) ;
  • Ahn, Chang-bum (Department of Acupuncture & Moxibustion College of Oriental Medicine, Dong-Eui University)
  • 투고 : 2003.05.12
  • 심사 : 2003.07.12
  • 발행 : 2003.08.20
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초록

This study was performed to determine if Juglandis semen extract(JSE) has free radical scavenging and antioxidant activities. Superoxide anion generation by xanthine oxidase/xanthine and in neutrophils activated by phorbol-12, 13-dibutyrate was inhibited by JSE and its effect was dose-dependent. JSE also inhibited generation of $H_2O_2$ induced by glucose oxidase/glucose and in opossum kidney cells treated with antimycin A. JSE exerted a direct $H_2O_2$ scavenging effect. Exposure of opossum kidney cells to 1mM tBHP caused a significant increase in lipid peroxidation, which was prevented by JSE. JSE also prevented tBHP-induced LDH release. These data suggest that JSE has free radical scavenging and antioxidant activities. However, further studies should be carried out to find the active ingredient(s) of JSE that exerts radical scavenging action.

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