Journal of the Korean Academy of Clinical Electrophysiology (대한임상전기생리학회지)

The Korean Academy of Clinical Electrophysiology (대한임상전기생리학회)
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Anesthetic Effect of Lidocaine Gel by Phonophoretic Transdermal Delivery

음파영동 경피투과에 의한 Lidocaine Gel의 마취효과

  • Kim, Tae-Youl (Dept. of Physical Therapy, Dongshin University) ;
  • Choi, Sug-Ju (Dept. of Physical Therapy, Handong University Sun Lin Hospital) ;
  • Lee, Joon-Hee (Dept. of Physical Therapy, Gachongil College) ;
  • Kim, Young-Il (Dept. of Pharmaceutical Engineering, Konyang University) ;
  • Chung, Kyu-Ho (Pharmaceutical Research Lab. Ildong Pharmaceutical Co., Ltd)
  • 김태열 (동신대학교 물리치료학과) ;
  • 최석주 (한동대학교 선린병원 물리치료실) ;
  • 이준희 (가천길대학 물리치료과) ;
  • 김영일 (건양대학교 제약공학과) ;
  • 정규호 (일동제약중앙연구소 제제연구실)
  • Published : 2003.12.31
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Abstract

The purpose of this study investigated the anesthetic effects of lidocaine gel by phonophoretic transdermal delivery. The anesthetic effects were evaluated by two aspects as quantitative sensory testing and sensory nerve conduction study. Twelve healthy males(aged $23.25{\pm}2.09$ years) were studied. Exclusion criteria were ; pain, history of sensory disturbances and skin conditions in the areas to be examined. The subjects were divided into two groups; group I(lidocaine gel without ultrasound) and group II(lidocaine gel with ultrasound). The following results were obtained; 1. In changes of tactile threshold and electrical pain threshold, all groups were significantly increased(p<0.05). 2. In changes of electrical pain threshold, it was significantly differenced between the groups(p<0.05). We conclude that the transdermal delivery of lidocaine gel by phonophoresis has a possibility to use for surface anesthesia and the pain control of the superficial tissue.

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