Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

A Retrospective Analysis of Treatment-Related Prognostic Factors for Local Recurrence after Primary Radiation Therapy for Patients with Primary T1N0 Glottic Cancer

T1N0 성문암의 방사선치료관련 예후 인자 분석

  • Kim Su-Ssan (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Kim Sang-Yoon (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Nam Soon-Yuhl (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Choi Seung-Ho (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Cho Kyung-Ja (Departments of Pathology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Kim Jong-Hoon (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Ahn Seung-Do (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Shin Seong-Soo (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Song Si-Yeol (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Choi Eun-Kyung (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Lee Sang-Wook (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
  • 김수산 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 김상윤 (울산대학교 의과대학 서울아산병원 이비인후과) ;
  • 남순열 (울산대학교 의과대학 서울아산병원 이비인후과) ;
  • 최승호 (울산대학교 의과대학 서울아산병원 이비인후과) ;
  • 조경자 (울산대학교 의과대학 서울아산병원 병리과) ;
  • 김종훈 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 안승도 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 신성수 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 송시열 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 최은경 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 이상욱 (울산대학교 의과대학 서울아산병원 방사선종양학과)
  • Published : 2003.05.01
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Abstract

Objective: To analyze the treatment-related parameters after the radiotherapy of T1N0 squamous cell carcinoma of the glottic larynx. Materials and Methods: Between October 1989 and August 2000, 54 patients with histologically proven T1N0 squamous cell carcinoma of the glottic larynx who received definitive radiation therapy in Department of Radiation Oncology, Asan Medical Center were analyzed. They were all males with age ranged from 31 to 80 years (median 61 years). 1997 AJCC stages were 31 T1a, 23 T1b. Patients were treated with 4-MV X-rays with a parallel-opposed two-field technique. Ten patients received 66.0-68.4Gy at 1.2Gy per fraction twice daily, 21 patients received 64.8-66.6Gy at 1.8Gy per fraction once daily, and 23 patients received 66.0Gy at 2.0Gy per fraction once daily. Follow-up period was 16-119 months (median 56 months). Results: 5-year overall survival and local control rates for patients with T1 lesions were 87.0% and 88.5%, respectively. 5-year local control with larynx preservation rate was 90.5%. Host and tumor-related prognostic factors including age, stage, anterior commissure involvement and tumor bulk proved not to be significant. Only shorter overall treatment time among treatment-related factors had correlation with imporved local control. Conclusion: Comparable high local control rate with organ preservation was achieved with primary radiation therapy and salvage surgery. Shortening of overall treatment time is related to improved local control rate. To determine the optimal fractionation scheme, randomized trial is mandatory.

Keywords

References

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