Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

The Effects of ASARI HERBA CUM RADICE (AHCR) herbal acupuncture at St36 on ovalbumin-induced asthma in C57BL mouse

세신약침(細辛藥鍼)의 천식억제 및 면역조절효과에 대한 실험적 연구

  • Kim, Il-Gu (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Kim, Young-Il (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Hong, Kwon-Eui (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Lee, Hyeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Lee, Byung-Ryul (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun-Kyoung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University)
  • 김일구 (대전대학교 한의과대학 경혈학교실) ;
  • 김영일 (대전대학교 한의과대학 침구학교실) ;
  • 홍권의 (대전대학교 한의과대학 침구학교실) ;
  • 이현 (대전대학교 한의과대학 침구학교실) ;
  • 이병렬 (대전대학교 한의과대학 침구학교실) ;
  • 임윤경 (대전대학교 한의과대학 경혈학교실)
  • Published : 2004.03.27
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Abstract

Objectives and methods : The aim of this study was to investigate the effect of AHCR(ASARI HERBA CUM RADICE) herbal acupuncture at St36 on ovalbumin-induced asthma in mice. C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). Two experimental groups were treated with different concentrations(1%, 0.1%) of AHCR-HAS at Chok-samni (St36) for the later 8 weeks (3times/week). Results 1. Lung weight of the mice group treated with AHCR-HA decreased significantly compared with that of control group. 2. Total Leukocytes in BALF of the mice group treated wtih AHCR-HA decreased significantly compared with those of control group. 3. The number of Eosinophils in BALF of the mice group treated wtih AHCR-HA decreased significantly compared with that of control group. 4. The number of $Gr-1^+/CD11b^+,\;CCR3^+,\;CD4^+,\;CD3e^+/CD69^+,\;IgE^+/B220^+$ cells in the lungs of the mice group treated with AHCR-HA decreased significantly compared with that of control group. 5. The number of $CD8^+$ cells in the lungs of the mice group treated with AHCR-HA didn't show significant difference compared with that of control group. 6. The concentration of IgE, IL-13, IL-4 in serum of the mice group treated with AHCR-HA decreased significantly compared with that of control group. Conclusion We conclude that AHCR-HA is effective on OVA-induced asthma in C57BL/6 mouse.

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