Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Acupuncture at the Acupoint Yongok$(KI_2)$, Umgok$(KI_10)$, Sobu$(HT_8)$. Sohae$(HT_3)$ on Aquaporin-2 expression, RSNA, MAP, HR, serum ANP, renin and norepinephrine in Rats

족소음신경(足少陰腎經) 연곡(然谷).음곡(陰谷)과 수소음심경(手少陰心經) 소부(少府).소해(少海) 침자(鍼刺)가 신장(腎臟) Aquaporin-2 발현(發現)과 신교감신경활성(腎交感神經活性), 혈압(血壓) 및 혈청(血淸) ANP, renin, norepinephrine에 미치는 영향(影響)

  • Youn, Dae-Hwan (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Park, Chna-Kyu (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jeong-Sang (Dept. of Anatomy, College of Oriental Medicine, Dongshin University) ;
  • Chae, Woo-Seok (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Na, Chang-Su (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University)
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 박찬규 (동신대학교 한의과대학 경혈학교실) ;
  • 김정상 (동신대학교 한의과대학 해부학교실) ;
  • 채우석 (동신대학교 한의과대학 침구학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실)
  • Published : 2004.03.27
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Abstract

Objectives : This research was performed to investigate the effect of acupuncture at the $KI_2\;KI_{10}\;HT_8\;HT_3$, on Aquaporin-2(AQP2) expression related with the renal functions in rats. Methods : Acupuncture was performed during 100-seconds, 6-times, at 150-seconds intervals under anesthesia in rats. We observed rats' mean arterial pressure(MAP), heart rate(HR), renal sympathetic nerve activity(RSNA) during acupuncture and AQP2 expression by western blot method and atrial natriuretic peptide(ANP), renin, norepinephrine of plasma after decapitation. Results : The AQP2 expression was significantly increased in $HT_8$ group, but decreased in $KI_{10}$ group. Average MAP during 6-times acupuncture was significantly increased in $HT_8$ group. Average HR was significantly increased in $HT_8$ group, Average RSNA was increased in $KI_{10}$ group, but that was marginally increased in $KI_{10}$ group. Plasma renin concentration was increased in $KI_2,\;HT_3$, groups. Plasma ANP show a tendency to decrease in $KI_10\;HT_3$ groups, increased in $KI_2,\;HT_3$ but not significant. Plasma norepinephrine concentration was significantly decreased in $KI_{10},\;HT_3$ groups. Conclusions : These results suggested that acupuncture at $HT_8$ activate renal function to reuptake, but $KI_{10}$ show a decline on effect of AQP2 expression, blood pressure, nerve activity and renin.

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