The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function

  • Chae, Hee-Sun (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Kang, Yong-Koo (Biogrand Inc., Chung-Ang University) ;
  • Shin, Yong-Kyu (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Lee, Hyun-Jung (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Yu, Ji-In (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Kwang-Gill (Department of Sericultural and Entomology, National Institute of Agriculture Science Technology, RDA) ;
  • Yeo, Joo-Hong (Department of Sericultural and Entomology, National Institute of Agriculture Science Technology, RDA) ;
  • Kim, Yong-Sik (Departments of Pharmacology, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University) ;
  • Sohn, Dong-Suep (Departments of Thoracic & Cardiovascular Medicine, College of Medicine, Chung-Ang University) ;
  • Kim, Kyung-Yong (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Won-Bok (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Sang-Hyung (Departments of Neurosurgery, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University) ;
  • Kim, Sung-Su (Departments of Anatomy, College of Medicine, Biogrand Inc., Chung-Ang University)
  • Published : 2004.08.21
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Abstract

Amyloid ${\beta}-peptide\;(A{\beta})$ contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against $A{\beta}-induced$ toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated $A{\beta}-induced$ apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

Keywords

References

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