Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory Flavonoids: Modulators of Proinflammatory Gene Expression

  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2004.02.28
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Abstract

Plant flavonoids possess anti-inflammatory activity in vitro and in vivo. Although the action mechanisms are not fully understood, recent studies have clearly shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase and various cytokines. This review summarizes the recent findings of flavonoids modulating expression of proinflammatory molecules.

Keywords

References

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