Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Thrombin Inhibitors from Medicinal and Wild Plants

약용 및 야생식물로부터 트롬빈 저해물질의 탐색

  • Kwon, Yun-Sook (Department of Food and Nutrition, Andong National University) ;
  • Kim, Young-Sook (Department of Food and Nutrition, Andong National University) ;
  • Kwon, Ha-Young (Department of Food and Nutrition, Andong National University) ;
  • Kwon, Gi-Seok (The School of Bioresource sciences, Andong National University) ;
  • Kim, Kyung-Jae (Research Center for Natural & New materials, Daepyung Co.) ;
  • Kwon, Chong-Suk (Department of Food and Nutrition, Andong National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
  • 권윤숙 (안동대학교 식품영양학과) ;
  • 김영숙 (안동대학교 식품영양학과) ;
  • 권하영 (안동대학교 식품영양학과) ;
  • 권기석 (안동대학교 생명자원과학부) ;
  • 김경재 ((주) 대평 천연물신소재 개발연구소) ;
  • 권정숙 (안동대학교 식품영양학과) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 손호용 (안동대학교 식품영양학과)
  • Published : 2004.03.30
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Abstract

Inhibitory activities of 264 methanol extracts, which were prepared from different parts of 210 kinds of wild and medicinal plants, against human thrombin were evaluated. Based on the anti-coagulation activity determined by thrombin time and activated partial thromboplastin time, the 14 extracts were screened. The fibrinolytic activity, heat stability and inhibition of other proteolytic digestive enzymes, such as pepsin, papain, trypsin and chymotrypsin, of the 14 extracts were further determined, and Ginko biloba (herba), Ephedra sinica (radix), Reynoutria elliptica (herba), Amomum tsao-ko Crevost (fructus), and Magnolia officinalis Rehd. et Wils (bark) were finally selected as possible plant sources for anti-thrombosis agent. These results suggested that medicinal and wild plants could be the potential source of thrombin inhibitor.

Keywords

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