Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of the Inhibitory Activity of Medicinal Plants against Protein Tyrosine Phosphatase 1B

생약의 Protein Tyrosine Phosphatase 1B (PTP1B) 저해활성 검색

  • Hong, Jung-Hyun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Myung-Sun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Bae, Eun-Young (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Young-Ho (Department of Manufacturing Pharmacy, Chungnam National University) ;
  • Oh, Hyun-Cheol (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Oh, Won-Keun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Bo-Yeon (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
  • Published : 2004.03.30
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Abstract

Protein tyrosine phosphatase 1B(PTP1B) is thought to be a negative regulator in insulin signal-transduction pathway. Insulin-resistance by the activation of PTP1B is a hallmark of both type 2 diabetes and obesity. Thus, the compounds inhibiting PTP1B can improve insulin resistance and can be effective in treating type 2 diabetes and obesity. The methanol extracts of 160 herbal medicines were screened for the inhibitory activity against PTP1B. Among the tested extracts, methanol extracts of Amsonia elliptica, Areca catechu, Benincasa hispida, Morus alba, Salvia miltiorrhiza, Siegesbeckia orientalis, and Trichosanthes kirilowii showed relatively strong inhibitory activity against PTP1B.

Keywords

References

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