Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Effect of Flavonoids on Efflux and Cytotoxicity of Daunomycin

도노마이신의 세포 외 배출 및 세포 독성에 미치는 플라보노이드의 효과

  • 정수연 (이화여자대학교 약학대학) ;
  • 고은정 (이화여자대학교 약학대학) ;
  • 김나형 (이화여자대학교 약학대학) ;
  • 이화정 (이화여자대학교 약학대학)
  • Published : 2004.04.20
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Abstract

One mechanism which plays a prominent role in development of multi-drug resistance seen in cancer cells is the over-expression of P-glycoprotein (P-gp). It is known that compounds found in vegetables and fruits not only have anticarcinogenic properties but may also modulate P-gp activity. The effect of some dietary components on efflux of daunomycin (DNM), a P-gp substrate, was examined in P-gp over-expressed human uterine sarcoma cell line, MES-SA/DX5. The efflux of DNM from the cells was significantly inhibited by quercetin and verapamil, but not by 1-naphtyl-isothiocyanate (NITC). The $IC_{50}$ values for DNM in MES-SA/DX5 cells were increased by flavonoids (quercetin and fisetin), but not by NITC after 72 hour incubation with dietary constituents. In conclusion, flavonoids may play a role in the modulation of P­-gp activity in human uterine sarcoma cells.

Keywords

References

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