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Anti-wrinkle Effect of Pressure Sensitive Adhesive Hydrogel Patches Containing Ulmi Cortex Extract

유백피 추출물을 함유한 하이드로겔 패치의 주름 억제 효과

  • Published : 2004.06.20

Abstract

The decreasing effect of wrinkle on the pressure sensitive adhesive hydrogel patches containing ulmi cortex extract and sorbitol as the drug for anti-wrinkle were investigated. In this study, hydrogels were prepared by the crosslinking reaction of acrylic polymers and aluminum ions produced by L(+)-tartaric acid hydrolysis of the dihydroxy aluminum aminoacetates. The inhibition concentration of ulmi cortex extract on the collagenase exhibited at 0.01%. Furthermore, the moisturizing effect of hydrogel patches formulated with sorbitol was higher than that without it. In vivo animal test in hairless mouse showed that the ulmi cortex-loaded hydrogel patches had about 31.2% of anti-wrinkle effect compared to blank (before attaching the patches). Human test showed that only 33% of subjects showed the decreasing of wrinkle during 8 weeks. In conclusion, the model pressure sensitive adhesive hydrogel patches in this study would be pharmaceutically applicable for the wrinkle treatment on the facial skin.

Keywords

References

  1. H.J. Ji and S.I. Lee, The Korean Herbal Pharmacopoeia, Korea Food and Drug Administradon, pp. 295 (2002)
  2. C.M. Kim, M.K. Shin, D.K. Ahn and K.S. Lee, Dictionary of Chinese Medicines, Jeong Dam Press, 7, pp. 4319-4321 (1998)
  3. B.H. Son, J.H. Park and O.P. Jee, Catechin glycoside from ulmus davidiana, The Pharm. Soc. Kor., Abstracts (38th), pp. 193 (1989)
  4. S.S. No, Experimental study on the and-inflammatory and wound healing effect of ulmus parvifolia, Research Institute of Korean Medicine Thesis Collection, Taejeon University, 7, 837-852 (1998)
  5. N.D. Hong, Y.S. Rho, N.J. Kim and J.S. Kim, A study on efficacy of ulmi cortex, Kor. J. Pharmacogn., 21, 217-222 (1990)
  6. Y.T. Sohn and S.Y. Kim, Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids, Arch. Pharm. Res., 25, 556-559 (2002) https://doi.org/10.1007/BF02976618
  7. L.K. Pershing, J. Corlett and C. Jorgensen, In vivo Phamacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum, Agents. Chemother., 38, 90-95 (1994)
  8. S. Bian, J. Zheng, J.S. Kim, M.J. Choi and H.K. Chung, In vitro and in vivo studies of topical delivery system of gentisic acid in hairless mice, J. Kor. Pharm. Sci., 32, 161-164 (2002)
  9. M. Carafa, E. Santucci and G. Lucania, Lidocaine-loaded non-ionic surfactant vesicles: characterization and in vitro permeation studies, Int. J. Pharm., 231, 21-32 (2002) https://doi.org/10.1016/S0378-5173(01)00828-6
  10. N.A. Peppas and E.W. Merrill. PVA hydrogels; Reinforcement of radiation-crosslinked networks by crystallization, J. Polym. Sci. PoIym. Chem., Ed., 14, 441-457 (1976) https://doi.org/10.1002/pol.1976.170140215
  11. S.R. Stauffer and N.A. Peppas, Poly (vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing, Polymer, 33, 3932-3936 (1992) https://doi.org/10.1016/0032-3861(92)90385-A
  12. N.A. Peppas and A.G. Mikos, Preparation methods and structure of hydrogels : In HydrogeIs in Medicine and Pharmacy, Vol. 1, N.A. Peppas (Eds.), CRC Press, Boca Raton, FL, pp. 1-27 (1986)
  13. L. Brannon-Peppas, Preparation and characterization of crosslinked hydrophilic networks : In Absorbent Polymer Technology, L. Brannon-Peppas, R.S. Harland (Eds.), Elsevier, Amsterdam, pp. 45-66 (1990)
  14. J. Kost and R. Range, Properties and applications : In Hydrogels in medicine and pharmacy, Vol. 3, N.A. Peppas (Eds.), CRC Press, Boca Raton, FL, PP. 95-186 (1986)
  15. Y. Huang, W. Leobandung, A. Foss and N.A. Peppas, Molecular aspects of muco- and bio-adhesion: Tethered structure and site-specific surfaces, J. Controlled ReIease, 65, 63-71 (2000) https://doi.org/10.1016/S0168-3659(99)00233-3
  16. T.W. Lee, J.C. Kim and S.J. Hwang, Hydrogel patches containing triclosan for acne treatment, Eur. J. Pharm. Biopharm., 56, 407-412 (2003) https://doi.org/10.1016/S0939-6411(03)00137-1
  17. T. Fujimura, S. Moriwaki, Y. Takema and G. Imokawa, Epidermal change can alter mechanical properties of hairless mouse skin topically treated with 1, 25-dihydroxyvitamin D3, J. Dermatol. Sci., 24, 105-111 (2000) https://doi.org/10.1016/S0923-1811(00)00090-6
  18. P. Corcuff, J. Rigal and J.L. Leveque, Skin relief and aging, J. Soc. Cosmet. Chem., 34, 177-190 (1983)
  19. T.W. Lee and Y.H. Choi, Hydrogel composition, K.P. 20000012760A (2000)
  20. H.M. Daniel, A study in the epidemiology of 'crows feet,' Ann. Intern. Med, 75, 873-880 (1971) https://doi.org/10.7326/0003-4819-75-6-873
  21. M.J. Grove and J.J. Leyden, Optical profilometry: An objective method for quantification of facial wrinkles, J. Am. Acad. Dermatol. 21, 631-637 (1989) https://doi.org/10.1016/S0190-9622(89)70230-9
  22. C.E. Griffiths, T.S. Wang, T.A. Hamilton and J.J. Voorhees. A photonumeric scale for the assessment of cutaneous photodamage, Arch. Dermatol, 128, 347-351 (1992) https://doi.org/10.1001/archderm.128.3.347
  23. H.H. Kang, Anti-aging in cosmetics, J. Soc. Cosm. Sci. Kor., 23, 57-74 (1997)
  24. J.S. Weiss, C.N. Ellis and J.T. Headington, Topical tretinoin improves photo aged skin, A double blind vehicle-controlled study, J. Am. Med. Assoc., 259, 527-532 (1998)
  25. E. Schwartz, F.A. Cruickshank, J.A. Mezick and L.H. Kligman, Topical all-trans retinoic acid stimulates collagen synthesis in vivo, J. Invest. Dermatol, 96, 975-978 (1991) https://doi.org/10.1111/1523-1747.ep12476385
  26. J. Varani, J. Shayevitz, D. Perry, R.S. Mitra, B.J. Nickoloff and J.J. Voorhees, Retinoic acid stimulation of human dermal fibroblast proliferation is dependent on suboptimal extracellular Ca^2^+concentration, Am. J. Pathol., 136, 1275-1281 (1990)
  27. J. Varani, R.S. Mitra, D. Gibb, S.H. Phan, V.M. Dixit and R.S. Mitra Jr., All-trans retinoic acid stimulates growth and extracellular matrix production in growth-inhibited cultured human skin fibroblasts, J. Invest. Dermatol, 94, 717-723 (1990) https://doi.org/10.1111/1523-1747.ep12876294
  28. D.S. Rosenthal, D.R. Roop, C.A. Huff, J.S. Weiss, C.N. Ellis, T. Hamilton, J.J. Voorhees and S.H. Yuspa, Changes in Photoaged human skin following topical application of all-trans retinoic acid, J. Invest. Dermatol., 95, 510-515 (1990) https://doi.org/10.1111/1523-1747.ep12504718
  29. R. Hermitte, Aged skin, retinoids and alpha hydroxy acids, Cosmet. Toil 107, 63-67 (1992)
  30. C.M. Ditre, T.D. Griffin, G.F. Murphy, H. Sueki, B. Telegan, W.C. Johnson, R.Y. Yu and E.J. Van Scott, Effects of-hydroxy acids on photoaged skin: A pilot clinical, histologic and ultrastructural study, J. Am. Acad. Dermatol., 34, 187-195 (1996) https://doi.org/10.1016/S0190-9622(96)80110-1
  31. D.M. Roach, R.A. Fitridge, P.E. Laws, S.H. Millard, A. Varelias and P.A. Cowled, Up-regulation of MMP-2 and MMP-9 lead to degradation of type collagen during sketal muscle reperfusion injury: Protection by the MMP inhibitor, doxycycline, Eur. J. Vasc. Endovasc. Surg., 23, 260-269 (2002) https://doi.org/10.1053/ejvs.2002.1598
  32. S. Lamparter, S.H. Slight and K.T. Weber, Doxycycline and tissue repair in rats, J. Lab. Clin. Med., 139, 295-302 (2002) https://doi.org/10.1067/mlc.2002.122624

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