Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Inhibitory effects of dl-Puerol A in the root of Sophora japonica on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro

  • Toda, Shizuo (Department of Pharmaceutical Science, Kansai College of Oriental Medicine) ;
  • Shirataki, Yoshiaki (Faculty of Pharmaceutical Sciences, Josai University)
  • Published : 2004.09.30
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Abstract

The inhibitory effect of dl-puerol A as but-2-enolide isolated from Sophora japonica was investigated on copper ion-induced protein oxidative modification in vitro. It inhibited copper-induced protein oxidative modification. However, its inhibitory effect was a little weaker than that of $dl-{\alpha}-tocopherol$ as an antioxidant. The results demonstrated that dl-puerol A, one of but-2-enolides, might be of use in the oxidative stress.

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References

  1. Ellman GL. (1959) Tissue sulfhydryl group. Arch. Biochem. Biophys. 82, 70-77. https://doi.org/10.1016/0003-9861(59)90090-6
  2. Halvorsen B, Brude I, Devon CA. (1996) Effects homocystein on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein. J. Lipid Res. 37, 1591-1600.
  3. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
  4. Nakatani N. (2000) Phenolic antioxidants from herbs and spices. Biofactor 13, 141-146. https://doi.org/10.1002/biof.5520130123
  5. Nohara T, Kinjo J, Furusawa J, Sakai Y, InoueM, Shirataki Y, Ishibashi Y, Yokoe I, Kimatsu M. (1993) But-2-anolides from Pueraria lobata and revised structures of puerosode A, B, and sophoraside A. Phytochem. 33, 1207-1210. https://doi.org/10.1016/0031-9422(93)85050-2
  6. Paniwnyk L, Beaufoy E, Lorimer JP, Mason TJ. (2001) The extraction of rutin from flower buds of Sophora japonica. Ultra Sonochem. 8, 299-301. https://doi.org/10.1016/S1350-4177(00)00075-4
  7. Satomi Y, Nishino, Iwashima A, Torihara M, Tamai Y, Ito M. (1992) Inhibitory effects (1E, 3E, 5E, 7E)-5-hydroxy-4-(8-phenyl-1,3,5,7-octate-traenyl)-2(5H)-furanone on proliferation of human malignant tumor cells. Anticancer Drug Des. 7, 169-179.
  8. Shirataki Y, Tagaya Y, Yo koe I, Komatsu M. (1987) Sophoraside A, a new aromatic glycoside from the roots of Sophora japonica. Chem. Pharm. Bull. 35, 1637-1640. https://doi.org/10.1248/cpb.35.1637
  9. Shirataki Y, Yokoe I, Noguchi T, Tomimori T, Komatsu M. (1988) Studies on the constituents of Sophora species. XXII. Constituents of the root of Sophora mooracroftiana BETH ex BAKER. Chem. Pharm. Bull. 36, 2220-2225. https://doi.org/10.1248/cpb.36.2220
  10. Shirataki Y, Tanaka T, Ohyama M, Toda S, Inuma M. (2002) Stilbene oligomers in root Sophora mooracroftiana. Natural Med. 56, 139-142.
  11. Takeoka Y, Naiki M, Taguchi N, Imai H, Kurimoto Y, Morita S, Suehiro S. (1993) 2Buten4olide inihibits type II collageninduced arthritis in Lewis rats. Int. J. Immunopharmacol. 15, 803-810. https://doi.org/10.1016/0192-0561(93)90017-S
  12. Tang YP, Li YF, Hu J, Lou FC. (2002) Isolation and idetification of antioxidants from Sopjora japonica. J. Asian Nat. Prod. Res. 4, 123-128. https://doi.org/10.1080/10286020290027407
  13. Toda S, Shirataki Y. (2002) Inhibitory effects of isoflavones in Sophora mooracroftiana on lipid peroxidation by superoxide. Pharmaceut. Biol. 40, 422-424. https://doi.org/10.1076/phbi.40.6.422.8447