Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Effects of herbal acupuncture(Atratylodes japonica, Coix lachrymajobi, Ephedra sinica, Atratylodes japonica mixed with Coix lachrymajobi and Ephedra sinica mixed with Green tea) at Pungnyung(ST40) and Umnungchon(SP9) in obese Rats induced by high fat diet

고지방식이(高脂肪食餌)로 유발(誘發)된 비만백서(肥滿白鼠)모델에서 창출(蒼朮), 의이인(薏苡仁), 마황(麻黃), 창출합의이인(蒼朮合薏苡仁) 마황합록차(麻黃合綠茶) 약침(藥鍼)이 혈청지질(血淸脂質) 및 간기능(肝機能)에 미치는 영향(影響)

  • Youn, Dae-Hwan (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Kang, Ja-Don (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Joo, Joon-Sung (Dept. of Acupunture & Moxibustiont, College of Oriental Medicine, Dongshin University) ;
  • Chae, Woo-Seok (Dept. of Acupunture & Moxibustiont, College of Oriental Medicine, Dongshin University) ;
  • Na, Chang-Su (Dept. of Meridian and Acupoint,Dept. of Acupunture & Moxibustiont, College of Oriental Medicine, Dongshin University)
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 강자돈 (동신대학교 한의과대학 경혈학교실) ;
  • 주준성 (동신대학교 한의과대학 침구학교실) ;
  • 채우석 (동신대학교 한의과대학 침구학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실,침구학교실)
  • Published : 2004.02.29
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Abstract

Objective : This research was performed to investigate the effect of herbal acupuncture(Atratylodes japonica, Coix lachrymajobi, Ephedra sinica, Atratylodes japonica mixed with Coix lachrymajobi and Ephedra sinica mixed with Green tea) at Pungnyung(ST40) and Umnungchon(SP9) on weight gain, food intake, food efficiency, serum of lipid concentrations, liver function and HDL to total cholesterol ratio of rats fed high fat diet for 5weeks. Method : Experimental groups were divided into normal group(Normal), high fat diet group(Control), high fat diet and Atractylodes japonica-herbal acupuncture group(AJ), high fat diet and Coix lachrymajobi-herbal acupuncture group(CL), high fat diet and Ephedra sinica-herbaI acupuncture group(ES), high fat diet and Atractylodes japonica+Coix lachrymajobi-herbal acupuncture group(AJ+CL), Ephedra sinica+Green tea-herbal acupuncture group(ES+GT). Herbal acupuncture was bilaterally treated at the level of 132.5mg/kg body weight per 2day. Results : Body weight and food efficiency were decreased in AJ, ES, AJ+CL, ES+GT. The level of serum total cholesterol, triglyceride and free fatty acid were increased in AJ, ES, ES+GT. That of serum HDL-cholesterol was increased in AJ. The change of food intake, the level of serum phospholipid and ALP were not significant. The HDL to Total cholesterol ratio was increased in AJ and ES. Conclusion : Atractylodes japonica-herbal acupuncture in ST40 SP9 is effective on Body weight, food efficiency ratio, the level of serum lipid, protection of liver function and prevention cardiovascular risk by obesity induced by high fat diet. Herbal acupuncture mixed Ephedra sinica with Green tea can control the body weight, food efficiency ratio and the level of serum lipid.

Keywords

References

  1. 김진규. 임상지질학. 서울. 의학출판사 .1992: 241-70
  2. Lee HK. Korean disease pattern and nutrition. Korea J Nutr. 1996;29:381–3.
  3. 郭靄春 編著. 黃帝內經靈樞校注語釋. 天津. 天津科學技術出版社. 1989 : 63,289-94,392-7.
  4. 龔廷賢. 萬病回春. 서울. 행림서원. 1982 : 220(上卷),1(下卷)
  5. 虞天民. 醫學正傳. 서울. 성보사. 1986 : 75
  6. 李梴. 編註醫學入門. 서울.: 대성문화사. 1974 : 323(外集券一), 108(外集卷二)
  7. 張介賓. 張氏類經. 서울. 성보사. 1982 : 586
  8. 中醫硏究院主編. 中醫證狀鑑別診斷學. 北京. 人民衛生出版. 1987. 43
  9. 楊東喜 編著. 本草備要解析. 서울. 일중사. 1991 : 371-2.
  10. 繆希雍 撰. 神農本草經疏. 北京. 中國中醫藥出版社. 1997 : 203.
  11. 전국한의과대학본초학교실. 본초학. 서울. 영림사. 1994 : 121-3, 306-8
  12. 전국한의과대학침구.경혈학교실 편저. 침구학. 서울. 집문당 1993: 387-8,407-8, 1017
  13. 羅昌洙 編著. 經絡.學各論. 서울. 정문각. 1989 : 65-6,78-9
  14. 김정연, 송용선. 비만에 대한 동서의학적 고찰. 동의물리요법과학회지. 1993 ; 3(1) : 299-314
  15. 박상용, 이병렬. 비만치료에 대한 침구 및 약물치료의 임상적 연구. 대전대학교 한의학연구소 한의학논문집. 1994; 2(2) : 163-85
  16. 성태수, 손규목, 배만종, 최정. 오갈피의 열수추출액이 고지방식이에 의한 비만유도 흰쥐의 지방 축적에 미치는 영향. 한국영양식량학회지. 1992 ; 21 (1): 9-16
  17. 이영주, 박무희, 황성원, 배만종, 한준표. 송화분이 고지방 식이 흰쥐의 혈청과 간장에 미치는 영향. 한국영양식량학회지 .1994; 23(2) : 192-7
  18. 선미경, 한성희. 서목태(Rhynchosia nulubilis) 추출물이 고지방 및 고콜레스테롤 식이 급여 흰쥐의 혈청 지질 농도에 미치는 영향. 한국식생활문화학회지.2002; 17(1) : 64-9
  19. 한은경, 성인숙, 문혜경, 조수열 더덕 물수출물이 고지방식이를 급여한 흰쥐의 체내 지질수준에 미치는 영향. 한국식품영양과학회지. 1998 ; 27(5) : 940-4
  20. Buemann B, Marckmann P, Christensen NJ, Astrup A. The effect of ephedrine plus caffeine on plasma lipids and lipoproteins during a 4.2MJ/day diet. International J. Obesity. 1994 ; 18 : 329-32
  21. 조은정, 류병호, 송병권, 이태훈, 서판길, 류성호, 김희숙. 마황으로부터 췌장 Cholesterol Esterase 저해 물질 분리 및 규명. 한국식품영양과학회지. 1999 ; 28(4) : 816-21
  22. Sin MK, Han SH, Han GJ. The effects of green tea on the serum lipid and liver tissue cholesterol fed rat. Kor. J Food Sci. Technol. 1997; 6: 1255-63
  23. Muramastsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol fed rats. J Nutr Sci Vitaminal. 1986; 2(6) : 613-22
  24. Vinson JA, Dabbagh YA. Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in hamster; Mechanisms for the epidemiological benefits of tea drinking. FEBS Lett. 1998; 33: 44-6 https://doi.org/10.1016/S0014-5793(98)00880-1
  25. 한한수. SPSS 를 활용한 통계자료분석. 서울. 청문각 1999: 171-204
  26. 이종호. 비만증의 치료. 대한비만학회지. 1992; 1(1) : 21-4
  27. Nilsson-Ehle P, Garfinkel AS, Schotz Me. Lipolytic enzymes and plasma lipoprotein metabolism. Annu Rev Biochem. 1980; 49: 667-93 https://doi.org/10.1146/annurev.bi.49.070180.003315
  28. Yamamoto A, Temba H, Horibe H, Mabuchi H, Saito Y, Matsuzawa Y, Kita T, Nakamura H. Life style and cardiovascular risk factors in the Japanese population-from an epidemiological survey on serum lipid levels in Japan 1990 part 2: association of lipid parameters with hypertension. J Atheroscler Thromb. 2003;10(3):176–85. https://doi.org/10.5551/jat.10.176
  29. Poirier P, Despres JP. Impact of obesity in contemporary cardiology. Med Sci. 2003;19(10):943–9.
  30. 강재헌. 비만의 약물요법. 대한의사협회지. 1999 ; 478: 1106-11
  31. 김인홍. 운동요법, 운동요법, 운동.행동수정요법이 중년 비만여성의 비만도, 혈중지질 및 자아존중감에 미치는 효과. 대한간호학회지. 2002; 32(6) : 844-54
  32. 김용성. 최신 비만 치료제. 대한내분비학회지. 2001;16(1):9–15
  33. 김지복, 주재식. 비만과 외과적 치료법. 대한의학협회지. 1986;29(12) : 1297
  34. 박혜순. 비만과 체중조절. 가정의학회지. 1992; 13 : 289-99
  35. 의학교육연수원 편. 가정의학. 서울. 서울대학교 출판부.1987: 281-3, 259-62
  36. 문헌기. 임상내분비학. 서울. 고려의학. 1990: 457-87
  37. 이문호 외 2 인. 내과학. 서울. 학림사. 1986: 337-8
  38. 劉河間. 劉河間三六書. 서울. 성보사 .1976: 82
  39. 李東桓. 東桓醫書 十種 牌뿜論. 서울. 대성문화사. 1983 : 70
  40. 裵秉哲 譯. 今釋黃帝內經素問. 서울. 성보사. 1978 : 305-15, 437-44
  41. Satoh K, Yasuda I, Nagai F, Ushiyama K, Akiyama K, Kano I. The effects of crude drugs using diuretic on horse kidney (Na+ + K+)-adenosine triphosphatase. Yakugaku Zasshi. 1991;111(2):138–45. https://doi.org/10.1248/yakushi1947.111.2_138
  42. 고석태, 김성오. 창출이 개의 신기능에 미치는 영향. 서울. 대한약제학회지. 1973; 3: 23-33
  43. 洪思岳, 文東淵. 蒼朮 Alkaloid가 Schedule Controlled Behavior에 미치는 影響. 韓藥理學雜誌. 1968;4(1):33–6.
  44. Chung BS, Suzuki H, Hayakawa S, Kim JH, Nishizawa Y. Studies on the plsama cholesterol-lowering componet in Coix, Nippon Shokikin Kogyo Gakkaishi. 1988;35:618–23. https://doi.org/10.3136/nskkk1962.35.9_618
  45. Ukita T, Tanimura A. Studies on the anti-tumor componet in the seeds of Coix lachryma-jobi L. var Ma-yeun(Rome.). Chem. Pharm. Bull. 1961;9:43–6. https://doi.org/10.1248/cpb.9.43
  46. 陳瑞準, 葉顯純, 王芳. 實用中藥手冊. 上海. 上海科學技術出版社. 1991: 532-3.
  47. 許俊. 東醫寶鑑. 서울. 남산당. 1994: 72,743
  48. 陸羽著, 朴良淑解譯. 茶經. 서울. 자유문고. 1998:18
  49. 張璐. 本經逢原. 北京: 中國中醫藥出版社. 1996 : 175-6
  50. Hasegawa N, Yamda N, Mori M. Powdered green tea has antilipogenic effect on Zucker rats fed a high-fat diet. Phytother Res. 2003;17(5):477–80. https://doi.org/10.1002/ptr.1177
  51. Yan Y, Zhao X, Zhang L, Liu F. Effect of a complex tea on reducing blood lipid in rabbits. Wei Sheng Yan Jiu. 2001;30(1):52–4
  52. Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. British Medical J. 1995;310:693–6. https://doi.org/10.1136/bmj.310.6981.693
  53. Yukihiko Hara, Fumiko Tono-oka. Hypotensive effect of tea catechins on blood pressure of rats. J. japanese Soc. Food Nur. 1990;43(5):345–8. https://doi.org/10.4327/jsnfs.43.345
  54. Akinyanju P, Yudkin J. Effect of coffee and tea on serum lipids in the rats. Nature. 1967 ; 214 : 1025 https://doi.org/10.1038/2141025a0
  55. 劉建洪, 河冬梅. 穴位藥物注射療法. 江西城. 江西科技. 1989 : 32-3
  56. 이규범. 임상병리핸드북. 서울. 고문사 1992 : 116-22,148
  57. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20(4):470–5.
  58. Gordon T, Kannel WB, Castelli WP, Dawber TR. Lipoproteins, cardiovascular disease, and death. The Framingham study. Arch Intern Med. 1981;141(9):1128–31 https://doi.org/10.1001/archinte.141.9.1128
  59. Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med. 1991;325(6):373–81. https://doi.org/10.1056/NEJM199108083250601
  60. 김기홍. 검사조직의 임상적 활용. 서울. 고문사. 1980. 164-77
  61. 손이식. 한국인의 고질혈증에 관한 연구(1)-1. 정상인 및 고혈압증에 있어서의 각종 질환에서의 고질혈증. 대한의학협회지. 1975;18:345–54.
  62. 양충모, 이재익, 김선주, 송병상, 이동후, 박성철, 손이석. 한국인에 있어서 각종 질환에서의 고지혈증 형별양상에 관한 연구. 대한의학협회지. 1980;23:151–9.
  63. 박금수, 이웅구, 조승연, 심원흠, 정남식, 장양수, 최경훈. 한국인 관상동맥질환에서 혈청지단백의 변화에 관한 연구. 순환기. 1986;16:531–41.
  64. Narayan KA, McMullen JJ. The interactive effect of dietary glycerol and corn oil on rat liver lipids, serum lipids and serum lipoproteins. J Nutr. 1979;109(11):1836–46 https://doi.org/10.1093/jn/109.11.1836

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