Hepatoprotective and antifibrotic effects of extracts from Persicae Semen

도인 추출물의 간보호 및 항섬유화 효과

  • 남극성 (원광대학교 약학대학 약학과) ;
  • 박은전 (원광대학교 약학대학 약학과) ;
  • 손동환 (원광대학교 약학대학 약학과) ;
  • 고건일 (원광대학교 약학대학 약학과)
  • Published : 2004.12.30

Abstract

This study was carried out to investigate the liver protective effects of extracts from Persicae Semen (WT-003, WT-005, WT-006). The acute hepatic injury was induced by intraperitoneal injection of alpha-naphtylisothiocyanate (75 mg/kg, p.o.) and treated with WT-006 (100 mg/kg/day, 200 mg/kg/day, 400 mg/kg/day). The experimental hepatic fibrosis was induced by bile duct ligation/scission(BDL/S), duration of 4 weeks and treated with WT-003, WT-005 or WT-006 (200 mg/kg/days for 4 week). In acute liver injury, WT-006 (200 or 400 mg/kg) lowered serum alanine transferase(ALT) and aspartate transferase(AST) significantly. In fibrotic rats, WT-006 treatment inhibited the hydroxyproline deposition in liver and lowered serum AST, ALT and ALP, significantly. These results suggest WT-006 extract, which does not contain amygdalin, from Persicae Semen have liver protective and antifibrotic effects in rats.

Keywords

References

  1. Hepatotoxicology Meeks, R.G.;Harrison, S.D.;Bull, R.J.
  2. J. Hepatol. v.38 Liver fibrosis-from bench to bedside Friedman, S.L.
  3. Wakanyaku Akamatsu, K.
  4. Kanpouiyakudaiziten v.II Tin, S.
  5. Arch. Pharm. Res. v.24 Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats Nan, J.X.;Park, E.J.;Yang, B.K.;Song, C.H.;Ko, G.;Sohn, D.H.
  6. Anal. Biochem. v.112 A simple method to determine nanogram levels of 4-hydoxyproline in biological tissue Jamall, I.S.;Finelli, V.N.;Que Hee, S.S.