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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Genetic Polymorphism of Glutathione S-transferase P1 and Breast Cancer Risk

  • Kim, Sook-Un (Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute) ;
  • Lee, Kyoung-Mu (Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute) ;
  • Park, Sue-Kyung (Department of Preventive Medicine, Konkuk University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute) ;
  • Noh, Dong-Young (Department of Surgery, Seoul National University College of Medicine, Cancer Research Institute) ;
  • Choe, Kook-Jin (Department of Surgery, Seoul National University College of Medicine, Cancer Research Institute) ;
  • Ahn, Sei-Hyun (Department of Surgery, Asan Medical Center, Ulsan University College of Medicine) ;
  • Hirvonen, Ari (Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute)
  • Published : 2004.09.30
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Abstract

To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFLP was used for the GSTP1 genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTP1 Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95% CI = 0.10 - 0.74). A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95% CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95% CI = 0.27-0.93). Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.

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References

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