Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Multifocal interstitial nephritis of pigs slaughtered in Jeju

제주지역 도축돈의 간질성 신염

  • Yang, Hyoung-Seok (Department. of Veterinary Medicine, Cheju National University) ;
  • Yang, Na-Yeon (Department. of Veterinary Medicine, Cheju National University) ;
  • Kang, Wan-Cheul (Animal Health Department of Jeju Provincial Institute for Livestock Promotion) ;
  • Kang, Sang-Chul (Department. of Veterinary Medicine, Cheju National University) ;
  • Kang, Hong-Won (Department. of Veterinary Medicine, Cheju National University) ;
  • Kim, Jae-Hoon (Department. of Veterinary Medicine, Cheju National University) ;
  • Bae, Jong-Hee (Department. of Veterinary Medicine, Cheju National University)
  • Accepted : 2004.05.06
  • Published : 2004.06.30
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Abstract

Total 160 head of porcine kidneys were examined for gross and histopathological lesions and polymerase chain reaction (PCR) for porcine circovirus type 2 (PCV-2), porcine parvovirus (PPV), Leptospira species and porcine reproductive and respiratory syndrome virus (PRRSV). Grossly, 137 kidneys (85.6%) had lesions characterized by the presence of the scattered white foci. Microscopically, multifocal interstitial nephritis, which classified into 4 grades such as, no lesion (Score 0), mild lesion (Score 1), moderate lesion (Score 2) and severe chronic lesion (Score 3) with fibrosis, was observed in 159 cases (99.4%). The histopathologic mean score for multifocal interstitial nephritis was significantly different (P<0.05) between the cases of PCV-2 single infection and the cases of co-infection with PCV-2 and PPV. According to PCR evaluation, PCV-2 were detected in 73.8% (118 cases), PPV were in 66.9% (107 cases), however Leptospira spp. and PRRSV were negative in all kidneys. Both PCV-2 and PPV were detected in 52.5% (84 cases). In 84 cases co-infected with PCV-2 and PPV, the occurrence of lymphoid follicle and vasculitis were observed as 65.5% (55 cases) and 26.2% (22 cases), respectively. These results revealed that PCV-2 and PPV were major infectious agents for interstitial nephritis in slaughtered pigs, Jeju. And the histopathologic lesions of multifocal interstitial nephritis were more severe in the case co-infected with PCV-2 and PPV.

Keywords

References

  1. 백영기, 임병무. 자연 발생한 돼지의 신장 빌병에 관한 병리학적 연구. 대한수의학회지. 1989, 29, 559-565
  2. 임창형, 이준섭, 정운익. 돼지 신염에 관한 병리학적 조사연구. 농사시험연구논문집. 1985, 27, 46-51
  3. Alexandersen, S. Parvovirus in pigs with multifocal interstitial nephritis. Vet. Rec. 2002, 150, 192
  4. Allan, G. M., Meehan, B., Todd, D., Kennedy, S., McNeilly, F., Ellis, J., Clark, E. G., Harding, J., Espuna, E., Botner, A. and Charreyre, C. Novel porcine circoviruses from pigs with wasting disease syndromes. Vet. Rec. 1998, 142, 467-468
  5. Chappel, R. J., Prime, R. W., Millar, B. D., Mead, L. J., Jones, R. T. and Adler, B. Comparison of diagnostic procedures for porcine leptospirosis. Vet. Microbiol. 1992, 30, 151-163
  6. Christopher-Hennings, J., Nelson, E. A., Nelson, J. K., Hines, R. J., Swenson, S. L., Howard, T. H., Zimmerman, J. J., Katz, J. B., Yaeger, M. J., Chase,C. C. L. and Benfield, D. A. Detection of porcine reproductive and respiratory syndrome virus in boar semen by PCR. J. Clin. Microbiol. 1995, 33, 1730-1734
  7. Clark, E. G. Post-weaning multisystemic wasting syndrome. Proc. Am. Assoc. Swine Pract. 1997, 28, 499-501
  8. Cooper, V. L., Heese, R. A. and Doster, A. R. Renal lesions associated with experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection. J. Vet. Diagn. Invest. 1997, 9, 198-201
  9. Drolet, R. and Dee, S. A. Disease of swine. pp. 959- 976, 8th ed. Iowa state university press, Ames, Iowa, 1999
  10. Drolet, R., D’allaire, S., Larochelle, R., Magar, R., Ribotta, M. and Higgins, R. Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter. Vet. Rec. 2002, 150, 139-143
  11. Ellis, W. A. Disease of swine. pp. 483-493, 8th ed. Iowa state university press, Ames, Iowa, 1999
  12. Jones, T. C., Hunt, R. D. and King, N. W. Veterinary Pathology. pp. 1111-1147, 6th ed. Lippincott Williams and Willkins, Philadelphia, 1997
  13. Kee, S. H., Kim, I. S., Choi, M. S. and Chang, W. H. Detection of leptospiral DNA by PCR. J. Clin. Microbiol. 1994, 32, 1035-1039
  14. Kelly, D. F. Pathology of extranasal lesions in experimental inclusion-body rhinitis of pigs. Res. Vet. Sci. 1967, 8, 472-478
  15. Larochelle, R., Antaya, M., Morin, M. and Magar, R. Typing of porcine circovirus in clinical specimens by multiplex PCR. J. Virol. Methods. 1999, 80, 69-75
  16. Ramos-Vera, J. A, Duran, O., Render, J. A. and Craft, D. Porcine dermatitis and nephropathy syndrome in USA. Vet. Rec. 1997, 141, 479-480
  17. Rossow, K. D., Collins, J. E., Goyal, S. M., Nelson, E. A., Christoper-Hennings, J. and Benfield, D. A. Pathogenesis of porcine reproductive and respiratorysyndrome virus infection in gnotobiotic pigs. Vet. Pathol. 1995, 32, 361-373
  18. Scanziani, E., Sironi, G. and Mandelli, G. Immunoperoxidase studies on leptospiral nephritis of swine. Vet. Pathol. 1989, 26, 442-444
  19. Shadduck, J. A., Koestner, A. and Kasza, L. J. The lesions of porcine adenoviral infection in germfree and pathogen-free pigs. Pathol. Vet. 1967, 4, 537-552
  20. Soares, R. M., Durigon, E. L. and Bersano, J. G. Detection of porcine parvovirus DNA by the polymerase chain reaction assay using primers to the highlyconserved nonstructural protein gene, NS-1. J. Virol. Methods. 1999, 78, 191-198
  21. Thomas, F. B., Scott, A. M., John, F. P. and Alan, H. M. The prevalence of leptospirosis and its association with multifocal interstitial nephritis in swine at slaughter. Can. J. Vet. Res. 1989, 53, 290-294
  22. Thomson, J. R., Higgins, R. J., Smith, W. J. and Done, S. H. Porcine dermatitis and nephropathy syndrome. Clinical and pathological features of casesin the United Kingdom (1993-1998). J. Vet. Med, A. 2002, 49, 430-437