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Global Genetic Analysis

  • Elahi, Elahe (Faculty of Science, Tehran University) ;
  • Kumm, Jochen (Stanford Genome Technology Center, Stanford University) ;
  • Ronaghi, Mostafa (Stanford Genome Technology Center, Stanford University)
  • Published : 2004.01.31

Abstract

The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.

Keywords

References

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