Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of an Oriental Herbal Composition, Jang Baek Union (JBU), on Alcohol-Induced Hangover and CCl4-Induced Liver Injury in Rats

한약재 조성물이 흰쥐의 알코올성 숙취 및 사염화탄소 유발 간 손상에 미치는 영향

  • 양동식 (한국한의학연구원 의료연구부) ;
  • 홍성길 (한국한의학연구원 의료연구부) ;
  • 최선미 (한국한의학연구원 의료연구부) ;
  • 김복남 (장백산간신약물연구소) ;
  • 성현제 (세명대학교 한의과대학) ;
  • 윤우식 (한국한의학연구원 의료연구부)
  • Published : 2004.01.01
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Abstract

Effects of the extract of oriental herbal composition, Jang Baek Union (JBU), on hangover and liver function were studied in rats. To investigate anti-hangover effect, alcohol concentration and acetaldehyde concentration of blood were measured after oral ethanol treatment. Blood alcohol concentration was significantly reduced by pre-treatment of JBU extract. The effect of JBU extract on the blood acetaldehyde concentration was more significant than commercial product used as a positive control. To investigate hepato-protective effect, serum GOT and GPT levels and histological changes of liver tissue were analyzed in $CCl_4$-treated rats. JBU extract adminstration significantly inhibited the increase of serum GPT and GOT levels induced by $CCl_4$-treatment. Moreover, histological injuries of liver tissue such as fatty changes and sinusoidal leukocytosis were inhibited by JBU extract.

본 연구에서는 숙취제거 및 간기능 개선에 전통적으로 사용되어온 한약재로 구성된 조성물 JBU의 효능을 동물실험을 통하여 검증하였다. 숙취제거 효능을 확인하기 위하여 알코올과 그 대사산물인 아세트알데히드의 혈중 농도를 측정한 결과, 혈중 알코을 농도에서 JBU 추출물 처리군은 대조군에 비해 유의적인 감소를 보였고, 특히 숙취의 원인물질로 지목되는 아세트알데히드 감소에 있어서도 유의적인 효과를 보였다. 간기능개선 효능의 확인을 위하여서는 사염화탄소 유발 간손상 동물모델에서 GPT와 GOT의 활성도를 측정하여 간손상 정도를 확인하였고, 조직병리학적 관찰을 통하여 간의 병적 변화를 관찰하였다. 사염화탄소는 확연하게 간손상을 유발시켰고, JBU 추출물은 GPT 및 GOT의 증가를 유의적으로 억제하였으며 조직학적으로도 간조직의 손상을 뚜렷하게 억제하였다.

Keywords

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