Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of a Alcohol Detoxification Beverage (ADB) Contained Radix puerariae and Bambusae caules in Liquamen Phyllostachyos on the Alcohol Administered Mouse

갈근(Radix Puerariae)과 죽력 (Bambusae caules in Liquamen Phyllostachyos)을 함유한 숙취해소 음료가 알코올을 투여한 생쥐에 미치는 영향

  • Published : 2004.02.01
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Abstract

This study has been carried out to investigate the effect of the beverage contained Radix puerariae (15%) and Bambusae caules in Liquamen Phyllostachyos (1%) on the alcohol administered mouse. The control group was treated with alcohol (40% alcohol, 8.0 mL/kg of body weight), experimental group 1 (Exp.1) was administered with beverage (8.0 mL/kg of body weight) before alcohol treatment, and experimental group 2 (Exp.2) was administered with beverage after alcohol treatment. Blood alcohol concentrations were decreased by 11% (in Exp. 1) and 17% (in Exp. 2) compared with control group. The concentrations of serum aspartate aminotransferase (AST) were slightly increased in Exp. 1 and Exp.2, but alanine aminotransferase (ALT) levels were not changed compared with control group. Mn-Superoxide dismutase activity was increased by about 70% in the experimental groups in comparison to control group. The Exp. 1 and Exp. 2 contained more periodic-acid Schiff (PAS)-positive materials than the control group. Electron microscopical observations showed that, cell organelles of hepatocytes were more disoriented in the control group than in Exp. 1 and Exp. 2. These results suggest that the beverage contained Radix puerariae and Bambusae caules in Liquamen Fhyllostachyos is a safe and effective therapeutic agent for alcohol abuse.

갈근(Radix puerariae, 15%)과 죽력 ( Cause in Liquamen Phyllostachyos, 1%)을 함유한 음료가 알코올을 투여한 생쥐에 미치는 영향을 구명 하고자 하였다. 대조군은 생쥐에 대조군은 생쥐에 알코올(40% alcohol, 8.0 mL/kg)을 단독 투여 하였으며, 실험 1군은 숙취 해소음료(8.0 mL/kg)를 투여한 다음 알코올을 투여하였고, 실험 2군은 알코올을 투여한 다음 동일음료를 투여하였다 실험 1군과 실험 2군의 알코올 농도는 대조군에 비하여 각각 유의성 있게 감소하였다. ALT활성 변화는 없었으나, AST의 활성은 실험 1군과 실험 2군에서 대조군에 비하여 다소 증가하였다. Mn-SOD의 활성은 대조군에 비하여 실험군에서 유의성 있게 증가하였다. 간조직의 PAS 반응은 대조군에 비하여 실험 1군과 실험 2군에서 높게 나타났다. 전자현미경을 통한 미세구조적 관찰 결과 실험 1군과 실험 2군에 비하여 대조군에서 세포소기관의 손상정도가 심하였다. 이상의 결과로 보아 갈근과 죽력을 함유한 기능성 음료는 숙취해소에 안전하고 효과적으로 사용할 수 있을 것이다.

Keywords

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