DOI QR코드

DOI QR Code

The Effects of Red-ginseng Intaking on Free Radical Produced During Aerobic Exercise in the Elderly

홍삼복용이 노인들의 유산소 운동시 발생된 활성산소에 미치는 영향

  • Choi, Jong-Hwan (Department of Exercise Science, Chungbuk National University) ;
  • Kim, Young-Soo (Department of pharmacy, Chungbuk National University) ;
  • Lee, Kyu-Moon (Department of Exercise Science, Chungbuk National University) ;
  • Kim, Hyeon-Ju (Department of Exercise Science, Chungbuk National University)
  • Published : 2004.03.01

Abstract

This study was performed to investigate the effect of 12 weeks red-ginseng intaking on MDA(malondialdehyde) produced during aerobic exercise in the young and elderly women. Sixteen volunteers agreed to participate and were placed in 2 groups: in the young(20-25 yrs), red-ginseng intake group(n=8), in the elderly(60-69 yrs), red-ginseng intaking group(n=8). The subjects who joined this study were asked to take 2.7g of red-ginseng powder capsule per day before the meal for 12 weeks(3 times/day). MDA(from blood samples) were collected at rest, just after the submaximal exercise, and 30 minutes after the exercise(cycle ergometer riding) at the beginning and the end of the 12-weeks program. After 12 weeks of red-ginseng intaking, young and elderly groups showed the decreased MDA significantly at rest(41.57%, 28.59%), just after the exercise(45.96%, 40.74%). and 30 minutes after the exercise(37.37%, 32.68%). These results indicate that red-ginseng intaking, as an antioxidant, may be useful for removing MDA produced during aerobic exercise in the elderly.

노인들의 고강도 유산소운동시 많은 산소요구량에 의하여 산화적인 스트레스가 증가하고, 결과적으로 함께 발생되는 활성산소는 MDA수준을 증가시킨다. 이렇게 노인들의 강도 높은 운동 중에 발생되는 활성산소에 홍삼복용이 어떠한 영향을 미치는 지를 알아보기 위하여 젊은이들과 비교하여 연구하였다. 노인들은 젊은이들과 함께 홍삼복용 전 후에 걸쳐 안정시, 운동직 후, 그리고 회복기 30분의 MDA수준이 유의하게 낮아진 것으로 나타났다. 따라서 홍삼복용은 젊은이들뿐만 아니라 노인들의 축적된 과산화지질을 제거하거나 과산화지질의 생성을 억제하는 항산화 효과가 있음을 시사한다.

Keywords

References

  1. Sjodin, B., Westing, H. Y. and Apple, F. S.: Biochemical mechanisms for oxygen free radical formation during exer-cise. Sports Med. 10, 236-254 (1990) https://doi.org/10.2165/00007256-199010040-00003
  2. 최진호 : 노화과정의 조절과 인삼의 효과. 제5회 생명과학심포지엄(한국인삼연초연구소). 2(5), (1993)
  3. Ji, L. L. : Exercise, oxidative stress, and antioxidants. American Journal of Sports Medicine. 42(6), S20-S24 (1996)
  4. Clarkson, P. M.: Antioxidants and physical performance, Criti. Rev. Food Sci. Nutri. 35(1-2), 131-141 (1995)
  5. Maxwell, S. R. : Prospects for the use of antioxidant therapies. Drugs. 49(3), 345-361 (1995) https://doi.org/10.2165/00003495-199549030-00003
  6. Renznik, A. Z., Steinhagan, T. E. and Gershon, D. : The effect of exercise on enzymes activities in cardiac muscle of mice of various ages. Biochermical Medicine. 28, 347-352 (1992) https://doi.org/10.1016/0006-2944(82)90089-8
  7. Kanter, M. M., Lesmes, G. R., Kaminsky, L. A., et al. : Serum creatine Kinase and lactate dehydrogenase changes following an eighty kilometer race.Eur.J.Appl. physiol. 57, 60-63 (1998) https://doi.org/10.1007/BF00691239
  8. Vihko, V., Salminen, A. and Rantamaki, J.: Oxdative lysosomal capacity inskeletal muscle of mice after endurance training. Acta Physiological Scandinavia. 104, 74-79 (1978) https://doi.org/10.1111/j.1748-1716.1978.tb06253.x
  9. 진영수, 류현승, 박준영, 이혁종, 김용권, 송욱, 지용석, 한구석 ; 운동강도에 따른 총항산화 MDA의 변화. 대한스포츠의학회지. 16(2), 265-270 (1998)
  10. Maughan, R. J., Donnelly, A. E., Gleeson, M., Whiting, P. H., Walker, K. A. and Clough, P.J.: Delayed onset muscle damage and lipid peroxidation in man after a downhill run. Muscle & Nerve. 12, 332-336 (1989) https://doi.org/10.1002/mus.880120412
  11. 한복기 : 노화의 이해: 활성산소와 노화현상. 대한화학회지. 38(2), (1998)
  12. Barakat, H. A., Dohm,G. L. and Shukl, N.: Influence of age and exercise training on lipid metabolisim in Fischer-344rats. J. Apply. Physiol. 67, 1638-1642 (1989)
  13. 최경묵, 이은종, 김용현, 백세현, 김영기, 최동섭 : 인슐린비의존성 당뇨병에서 홍삼이 적혈구의 지질 관산화 및 항산화효소 수퍼옥시드 디스뮤타제에 미치는 영향. Korea J. Genseng Sci. 21(3), 153-159 (1997)
  14. 정해영, 김규원, 정한영, 오미현, 양한석, 오우라히코끼치, 요꼬자와다까꼬 ; Ginseonside Rb2가 노화촉진마우스(SAM-R/1)의 항산화물질에 미치는 영향. 한국생화학회지. 29(3), 492-497 (1996)
  15. 전병선, 김나미, 박채규, 양재원, 장규섭 : CA 저장이 수삼 및 홍삼의 항산화 작용과 항암작용에 미치는 영향. 고려인삼학회. 20(3), 262-268 (1996)
  16. Shin, J. G., Park, J. W., Pyo, M. S., Kim, M. S, and Chung, M. H.;Kor. J. Ginseng Sci. 14, 189-190 (1990)
  17. 박미정, 송진호, 김선여, 김영중 : 약학회지. 34, 365-373 (1990)
  18. Choi, J. H. and Oh, S. K.: Kor. Biochem.J. 17, 445-455 (1984)
  19. Halliwell, B. and Gutteridge, J. M. C.: Free radicals in biology and medicine.oxford: Clarendon press. 1-18 (1985)
  20. Spirduso, W. W.: Physical dimension of aging. Champaignurbana; IL; Human Kenetics. (1995)
  21. Viguie, C.A., Frei, B.,Shignaga, M.K., Amees,B.N., Packer,L. and Brooks, G.A.: Antioxidant status and indexes of oxidative stress during consecutive days of exercise. Journal of Applied Physiology. 75(2), 566-572 (1993)
  22. Dillard, C. J., Litov, R.E. and Savin, W.M. : Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation. J. Apple. Physiol. 45, 927-932 (1978)
  23. Sumida, S. Tanaka, K., Kitao, H. and Nakadomo, F. : Execise induced lipid peroxidation and leakage of enzymes before and after vitaman E supplement int. J. Biochem. 21, 835-838 (1989)
  24. Maxwell, S. R. J., Jakemap, P. and Thomason, H. : Changes in plasma antioxidant status during exxentric exercise and the effect of vitamin supplementation. Free Radic ResCommun. 19, 191-201 (1993) https://doi.org/10.3109/10715769309111602
  25. Kanter, M.M., Nolte, L. A. and Holloszy, J. D.: Effect of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J. Appl. Physiol. 74(2), 965-969 (1993)
  26. Sastre,J., Aseni, M., Gasco, E., Pallardo, F. V., Ferrero,J.A., Furukawa, T. and Vima, J. : Exhaustive physical exercise causes oxidation of gluthione status on blood prevention by antioxidant administration. Am. J. Physiol. 263, 992-995 (1992)