Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of White and Red Panax ginseng Extract on Serum Lipids Level in High-fat-diet Fed Rats

백삼 및 홍삼추출물이 고지방 식이 급여 흰쥐의 혈청 지질 함량에 미치는 영향

  • Published : 2004.03.01
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Abstract

This study was carried out to determine the effect of white and red Panak ginseng on body weight gain, feed efficiency, epididymal fat weight, and total serum cholesterol and triglyceride levels in male rats (Wister/ST, 8-week-old, 320 g) fed high fat diet. Rats were divided largely into two groups; normal control (NC) and high-fat-diet (HFD)-fed groups. HFD-fed animals were subdivided into 2 groups; HFD-fed control (FC), and HFD- and ginseng-fed groups. HFD and ginseng fed animals were furthor subdivided into white (WG)- and red ginseng (RG)-treated groups. Ginseng-treated groups received ethanol extract at daily doses of 250, 500, 1,000 mg/kg b.w. for 4 weeks. Consequently, a total of 40 rats were divided into 8 groups. Body weight gain of WG-500 (P<0.05), WG1000 (P<0.01) and RG500 (P<0.05) was significantly lower than that of the NC. Feed efficiency showed same result. The epididymal fat weight of WG500, WG1000 and RG250 was markedly lower (P<0.05) than that in FC. Total serum cholesterol level of WG250, WG500, WG1000 and RG1000 groups were significantly lower (P<0.05) than that of FC. Decrease in the total cholesterol level was most significant in WG100 group. Treatment of ginseng significantly reduced serum free cholesterol and triglyceride levels of the HFD-fed rats irrespective of white or red ginseng. Among the test groups, administration of ginseng at daily dose of 1,000 mg/kg b.w. showed the most potent free cholesterol and triglyceride lowering activity. These results led us to the conclusion that administration of ginseng lowers serum total or free cholesterol and triglyceride levels in HFD-fed animals. Moreover the beneficial effect of white ginseng was slightly more potent than that of the red ginseng.

본 연구는 고지방 식이를 급여한 암컷 rat(wister/ST, 8주령, 320g)에서 백삼과 홍삼이 체중증가, 식이효율, 부고환 지방 무게 및 혈청 콜레스테롤과 triglyceride 수치에 미치는 영향을 측정하기 위하여 실행하였다. rat는 기초식이(NC)와 고지방식이(HFD)군으로 분리하고 고지방식이군은 고지방식이 대조군과 고지방식이 인삼 투여군으로 분리하였다. 또한 인삼식이군은 다시 백삼(WG)과 홍삼투여군(RG)으로 나누었다. 인삼투여군은 4주 동안 인삼 에탄올 추출물 250, 500, 1000 mg/kg b.w.를 투여하였다. 전체 40마리의 rat를 8군으로 분리하였다. WG-500(p<0.05), WG1000(p<0.01), RG500(p<0.05) 투여군의 체중 증가 및 식이 효율에서 대조군에 비해 유의성있게 낮게 나타났다. WG500, WG1000, RG250 투여군의 부고환 지방무게는 HFD에 비해 매우 낮게 나타났다(p<0.05). 또한 WG250, WG500, WG1000과 RG1000군의 혈청 콜레스테롤 수치가 HFD에 비해 유의하게 낮게 나타났다(p<0.05). 전체 콜레스테롤 수치는 WG100군에서 가장 많이 감소하였다. 백삼 투여군에서 혈청 유리 콜레스테롤 수치가 감소하였으나 HFD군의 triglyceride 수치는 백삼과 홍삼 모두 관련이 없었다. 매일 1,000 mg/kg b.w.를 먹인 실험군이 유리 콜레스테롤과 triglyceride 억제활성이 가장 크게 나타났다. 위 결과를 종합해 볼 때, 인삼의 복용은 고지방 식이 동물에서 혈청 전체 혹은 유리콜레스테롤과 triglyceride수치를 감소시키며, 백삼이 홍삼보다 더 강한 효능을 나타내었다.

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References

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