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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Antioxidant Properties of Some Novel Benzimidazole Derivatives on Lipid Peroxidation in the Rat Liver

  • Canan Kus (Department of Pharmaceutical Chemistry Ankara University) ;
  • Gulgun, Ayhan-Kilcigil (Department of Toxicology, Faculty of Pharmacy, Ankara University) ;
  • Eke, Benay-Can (Department of Toxicology, Faculty of Pharmacy, Ankara University) ;
  • Mumtaz Iscan (Department of Toxicology, Faculty of Pharmacy, Ankara University)
  • Published : 2004.02.01
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Abstract

Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1 H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84％ inhibition of LP at $10^{-3}$ M, which is better than that of butylated hydroxytoluene (BHT) (65％).

Keywords

References

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