Journal of Nutrition and Health

  • 제37권2호
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  • Pages.88-94
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  • 2004
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

운지버섯 균사체 배양액이 고지방 식이를 급여한 흰쥐의 지질대사 및 효소활성에 미치는 영향

Effects of Liquid Culture of Coriolus Versicolor on Lipid Metabolism and Enzyme Activities in Rats Fed High Fat Diet

  • 문상필 (신라대학교 생명과학과) ;
  • 고진복 (신라대학교 생명과학과)
  • 발행 : 2004.03.01
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초록

운지버섯 균사체 배양액이 고지방식이를 섭취한 숫쥐의 성장률, 장기무게, 지질 대사 및 효소활성에 미치는 영향을 조사하고자, 생후 7주령의 흰쥐 (255.3$\pm$20.2g)에 표준 식이를 급여한 정상군, 표준식이에 15% 돈지를 첨가한 식이를 급여한 고지방군, 고지방 식이에 운지버섯의 균사체 배양액을 음료수에 20% 및 30%로 혼합 급여한 군(20% 및 30% 운지버섯군) 등 4군으로 나누어 5주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량은 30% 운지버섯군이 고지방군에 비해 다소 감소되었다. 식이섭취량 및 식이효율, 그리고 간, 신장, 비장 및 췌장 및 부고환지방의 무게는 고지방군과 20% 및 30% 운지버섯군이 비슷한 수준으로 나타났다. 부고환지방은 정상군에 비해 고지방군 및 운지버섯군들이 유의하게 증가되어 운지버섯 섭취에 따른 감소 효과는 나타나지 않았다. 혈청과 간의 중성지질 농도는 고지방군에 비해 30% 운지버섯군이 유의하게 감소되었다. 혈청과 간의 총 콜레스테롤 농도는 정상군과 고지방군, 20% 및 30% 운지버섯군이 비슷하였다. 혈청의 HDL-콜레스테롤 농도 및 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 고지방군에 비해 운지버섯군이 유의하게 감소되었다. 동맥경화지수는 고지방군에 비해 20% 및 30% 운지버섯군이 유의하게 증가되었다. 혈청의 glutamic oxaloacetic transaminase, glutamic pyruvic transaminase 및 alkaline phosphatase 활성은 정상군과 각 실험군이 비슷한 경향이었다. 이상의 결과로 보아 고지방식이를 급여한 흰쥐에 운지버섯 균사체 액체배양액을 30% 급여 시 체중증가량과 장기 무게는 정상수준을 유지하였고, 혈청과 간의 중성지질 농도를 낮추는 효과가 나타났다.

The effects of liquid culture of Coriolus versicolor on weight gain, food intakes, food efficiency ratios, serum and hepatic lipid concentrations, serum protein levels and serum enzyme activities, were studied in growing male rats. Sprague-Dawley rats were given four different types of diets for a succeeding period of 5 weeks, respectively: a normal diet group (7% corn oil), a high fat diet group (7% corn oil＋15% lard), a 20% or 30% C. versicolor diet groups (high fat diet＋20% or 30% C. versicolor in water) according to the levels of C. versicolor supplementation. The body weight gains of the rats fed the 30% C. versicolor diets were lower than those in the rats fed high fat diet. The epididymal fat pad weight of the rats fed high fat diet and 20% or 30% C. versicolor diets were significantly higher than that of the rats fed normal diet. The concentrations of triglyceride in the serum and the liver of the rats fed the 30% C. versicolor diets were more significantly decreased compared to rats on the high fat diet. The concentrations of total cholesterol in the serum and the liver of rats fed the high fat diet, 20% and 30% C. versicolor diets were similar to those of rats fed the normal diet. The HDL-cholesterol concentration and the HDL-cholesterol/total-cholesterol ratio of the rats fed 20% and 30% C. versicolor diets were significantly lower than those of the rats fed high fat diet. But the antherogenic index of the rats fed 20% or 30% C. versicolor diets were significantly higher than those of the rats fed high fat diet. There were no differences in the activities of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase in the serum among the experimental groups. These results showed that the 30% C. versicolor diet feeding decreased the triglyceride in serum and liver of the rats.

키워드

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