Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Antimicrobial Activity of Vaccinium macrocarpon (Cranberry) Produced Proanthocyanidin (PAC) on the Growth and Adhesion Properties of Staphylococcus aureus

  • Hui, Jonathan (Ontario Science Centre) ;
  • Choy, John (Ontario Science Centr) ;
  • Suwandaratne, Sid P. (Ontario Science Centr) ;
  • Shervill, Jenna (Ontario Science Centr) ;
  • Gan, Bing S. (Lawson Health Research Institute, Canadian Research and Development Centre for Probiotic) ;
  • Howard, Jeffrey C. (Lawson Health Research Institute, Canadian Research and Development Centre for Probiotic) ;
  • Reid, Gregor (Lawson Health Research Institute, Canadian Research and Development Centre for Probiotics)
  • Published : 2004.03.01
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Abstract

Cranberries have long been used by lay people to relieve the symptoms of urinary tract infections. Recent research has determined that the component of cranberry called proanthocyanidin (PAC) is the primary mechanism for inhibiting P-fimbriated E.coli adhesion to uroepithelial cells in vitro. A series of experiments were performed to determine the effects of PAC on growth and adhesion of uropathogenic E. coli and Staphylococcus aureus to urinary catheter material. The results showed that PAC-inhibited binding of Gram positive S. aureus to collagen coated surfaces and significantly decreased the growth of these bacteria. P-fimbriated E.coli did not bind well to the biomaterial and their growth was unaffected by the cranberry extract with the exception of some loss in viability at 1000 $\mu\textrm{g}$/mL after 5 to 18 hours of exposure. This is the first report of the potential for cranberries to interfere with the adhesion and growth of S. aureus, a multi-drug resistant organisms responsible for morbidity and mortality especially in hospitalized patients.

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References

  1. J Lab Clin Med v.54 Cranberry juice and the antibacterial action of hippuric acid Bodel PT;Contran R;Kass EH
  2. J Sci Food Agr v.80 Review: proanthocyanidins and tannin-like compounds-nature, occurrence, dietary intake and effects on nutrition and health Santos Buelga C;Scalbert A https://doi.org/10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.0.CO;2-1
  3. J Infect Dis v.186 Epithelial differentiation promotes the adherence of type 1-piliated Escherichia coli to human vaginal cells Klumpp DJ;Forresta, SG;Karr JE;Mudge CS;Anderson BE;Schaeffer AJ https://doi.org/10.1086/345557
  4. Proc Natl Acad Sci USA v.101 Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis Justice SS;Hung C;Theriot JA;Fletcher DA;Anderson GG;Footer MJ;Hultgren SJ https://doi.org/10.1073/pnas.0308125100
  5. Cytometry v.50 Precise and rapid assessment of Escherichia coli adherence to vaginal epithelial cells by flow cytometry Stapleton AE;Fennell CL;Coder DM;Wobbe CL;Roberts PL;Stamm WE https://doi.org/10.1002/cyto.10046
  6. Antimicrob Agents Chemother v.33 Inhibitory activity of cranberry juice on adherence of type-1 and type p fimbriated Esherichia coli to eucaryotic cells Zafriri D;Ofek I;Adar R;Pocino M;Sharon N https://doi.org/10.1128/AAC.33.1.92
  7. New Engl J Med v.339 Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial cell surfaces by proanthocyanidin extracts from cranberries Howell AB;Vorsa N https://doi.org/10.1056/NEJM199810083391516
  8. J Nat Prod v.63 A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli Foo LY;Lu Y;Howell AB;Vorsa N https://doi.org/10.1021/np000128u
  9. Spinal Cord v.39 Cranberry juice consumption may reduce biofilms on uroepithelial cells: pilot study on spinal cord injured patients Reid G;Hsiehl J;Potter P;Mighton J;Lam D;Warren D;Stephenson J https://doi.org/10.1038/sj.sc.3101099
  10. Nutraceut Food v.8 Cranberry juice to reduced bladder biofilms and infection in geriatric and spinal cord injured patients with dysfunctional bladders Reid G;Potter P;Lam D;Warren D;Borrie M;Hayes K https://doi.org/10.3746/jfn.2003.8.1.024
  11. Cochrane Database Syst Rev v.1 Cranberries for preventing urinary tract infections Jepson R;Mihaljevic L;Craig J
  12. J Food Prot v.66 Inactivation of Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella in cranberry, lemon, and lime juice concentrates Nogueira MC;Oyarzabal OA;Gombas DE
  13. Medicine v.82 A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance Change FY;MacDonald BB;Peacock JEJr;Musher DM;Triplett P;Mylotte JM;O'Donnell A;Wagener MM;Yu VL https://doi.org/10.1097/01.md.0000091185.93122.40
  14. J Agric Food Chem v.51 Screening of foods containing proanthocyanidins and their structural characterization using LC-MS/MS and thiolytic degradation Gu L;Kelm MA;Hammerstone JF;Beecher G;Holden J;Haytowitz D;Prior RL https://doi.org/10.1021/jf034815d
  15. Biochemistry v.69 Anti-angiogenci, antioxidant, and anti-arcinogenic properties of a novel anthocyanin-rich berry extract formula Bagchi D;Sen CK;Bagchi M;Atalay M
  16. J Heart Valve Dis v.13 Warfarin and cranberry juice: an interaction? Grant P
  17. BJU Int v.92 Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation McHarg T;Rodgers A;Charlton K https://doi.org/10.1046/j.1464-410X.2003.04472.x
  18. Urology v.57 Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis Terris MK;Issa MM;Tacker JR
  19. J Urol v.148 Microbial adhesion and biofilm formation on ureteral stents in vitro and in vivo Reid G;Denstedt JD;Kang YS;Lam D;Nause C
  20. FEMS Immunol Med Microbiol v.16 Uropathogenic Escherichia coli adhere to urinary catheters without using fimbriae Reid G;van der Mei HC;Tieszer C;Busscher HJ https://doi.org/10.1111/j.1574-695X.1996.tb00132.x
  21. J Basic Microbiol v.40 Influence of cranberry juice on attachment of Escherichia coli to glass Allison DG;Cronin MA;Hawker J;Freeman S https://doi.org/10.1002/(SICI)1521-4028(200002)40:1<3::AID-JOBM3>3.0.CO;2-L
  22. Infect Immun v.70 Role of type 1 fimbria-and P fimbria-specific adherence in colonization of the neuro-genic human bladder by Escherichia coli Hull RA;Donovan WH;Del Terzo M;Stewart C;Rogers M;Darouiche RO https://doi.org/10.1128/IAI.70.11.6481-6484.2002

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