Archives of Pharmacal Research

  • 제27권3호
  • /
  • Pages.283-286
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  • 2004
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Pentacyclic Triterpenoids and Their Cytotoxicity from the Stem Bark of Styrax japonica S. et Z.

  • Kim, Mi-Ran (Research Center for Proteineous Materials, Chosun University) ;
  • Lee, Hyang-Hee (Research Center for Proteineous Materials, Chosun University) ;
  • Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University) ;
  • Moon, Young-Hee (College of Pharmacy, Chosun University) ;
  • Woo, Eun-Rhan (Research Center for Proteineous Materials, Chosun University and College of Pharmacy, Chosun University)
  • 발행 : 2004.03.01
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초록

The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol -3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.

키워드

참고문헌

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