Korean journal of food and cookery science (한국식품조리과학회지)

Korean Society of Food and Cookery Science (한국식품조리과학회)
권호 표지

Physiological Activity in Doenjang Added with Various Mushrooms

버섯첨가된장의 생리활성 작용

  • 이수진 (부산대학교 식품영양학과 및 김치 연구소) ;
  • 이경임 (양산대학 호텔조리) ;
  • 이숙희 (부산대학교 식품영양학과 및 김치 연구) ;
  • 박건영 (양산대학 호텔조리과)
  • Published : 2004.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

The study was carried out to evaluate the radical scavenging activity, and antimutagenic and anticancer effects in Korean soybean paste(doenjang) added with various mushrooms. Ganoderma lucidum doenjang(Gl-TD) showed significant inhibitory activity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, with an IC$\sub$50/ value of 245$\mu\textrm{g}$/$m\ell$. In contrast, the other doenjang varieties appeared to have weaker antioxidant activity. Four kinds of doenjang didn't have any antimutagenic activity against N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) by adding of 5mg/plate, but exhibited a strong inhibitory effect(55∼70%) against aflatoxin B$_1$(AFB$_1$). Especially Phellinus linteus doenjang(Pl-TD) inhibited more than 70% of the mutagenicity induced by AFB$_1$ in Salmonella typhimurium TA100. On the other hand, the mushroom doenjang varieties showed relatively weak activity toward MNNG in SOS chromotest, their inhibitory rate ranging from 23% to 33%. Methanol extracts of Gl-TD and Pl-TD inhibited by 91∼92% the growth of AGS gastric cancer cells in a concentration of 100$\mu\textrm{g}$/$m\ell$.

Keywords

References

  1. 송형익, 신중엽 : 현대 발효공학. p.234, 지구문화사, 서울, 1996
  2. Moon, SH : Antimutagenic effect of Doenjang(Korean soy paste). master thesis, Pusan National University, 1990
  3. Park, KY, Moon, SH, Baik, HS and Cheigh, HS : Antimutagenic effect of Doenjang(Korean fermented soy paste) toward aflatoxin. J. Kor. Soc. Food Nutr. , 19(2): 156, 1990
  4. Cheigh, HS, Lee, JS and Lee, CY : Antioxidative characteristics of melanoidin related products fractionated from fermented soybean sauce. J. Kor. Soc. Food Nutr., 22:570, 1993
  5. Choi, SY, Cheigh, MI, Lee, JJ, Kim, HJ, Hong, SS, Chung, KS and Lee, BK : Growth suppression effect of traditional fermented soybean paste(Doenjang) on the various tumor cells. J. Korean Soc. Food Sci. Nuri., 28(2):458, 1999
  6. Kim, GH and Han, HK : The effect of mushroom extracts on carbon tetrachloride induced hepatotoxicity in rats. J. Korean Soc. Food Sci. Nuri., 27:326, 1998
  7. Hartwell, JL : Plants used against cancer. A. Survey. Lloyda., 34:386, 1971
  8. Choi, JR, Ha, TM, Kim, YH and Rho, YD : Studies on the main factors affecting the mycelial growth of Phellinus linteus. Kor. J. Mycol., 24:214, 1996
  9. Ji, JR, Kim, MN, Chung, CK and Ham, SS : Antimutagenic and cytotoxicity effects of Phellinus linteus extracts. J. Korean Soc. Food Sci. Nutr., 29(2): 322, 2000
  10. Chang, ST, John, AB and Chiu, SW : Mushroom biology and mushroom products. World scientific, Washington, D.C., p.1-20, 1993
  11. Ji, JH, Kim, MN, Chung, CK and Ham, SS : Antigenotoxic effects of Phellinus linteus and Agaricus blazei Murill extracts. J. Korean Soc. Food Sci. Nutr., 29(3):513, 2000
  12. Kweon, MR, Lim, EJ and Sung, HJ : Studies on biological polysaccharides isolated from Agaricus bisporus (in Korean). J. Kor. Agric. Chem Biotechnol., 41:60, 1998
  13. Gom, C, Junji, H, Yukiko, Y, Yoshiko, A and Fumoko, F : Fractionation and purification of the polysaccharides with masked antitumor activity, especially lentinan from Lentinus edodes. Cancer Res., 30:2776, 1970
  14. Kim, SW : Studies on anti-microbial and anti-cancer functions of polysaccharide extracted Ganoderma lucidum. J. Korean Soc. Food Sci. Nutr., 27:1183, 1988
  15. Lee, Kl, Moon, RJ, Lee, SJ and Park, KY : The quality assessment of doenjang added with Japanese apricat, garlic and ginger, and samjang. Korean T. Soc. Food Cookery Sci., 17(5):472, 2001
  16. Lee, Kl, Kwon, SJ and Moon, RJ The taste components composition in various mushrooms-added Korean soybean paste(Doenjang). The Korean J. Community Living Science, 13(1):41, 2002
  17. Hatano, T, Edamatsu, R, Hiramatsu, M, Mori, A, Fujita, Y, Yasuhara, T, Yoshida, T and Okuda, T : Effects of the interactions of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull., 37:2016, 1989 https://doi.org/10.1248/cpb.37.2016
  18. Maron, DM and Ames, BN : Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113: 173, 1983 https://doi.org/10.1016/0165-1161(83)90010-9
  19. Ames, BN, McCann, J and Yamasaki, E : Methods for detecting carcinogens and mutagens with the Salmonella mammalian-microsome mutagenicity test. Mutat. Res., 31:347, 1975 https://doi.org/10.1016/0165-1161(75)90046-1
  20. Quillardet, P and Hofnung, M : The SOS chromotest a colorimetric bacterial assay for genotoxins. Mutat. Res., 147:65, 1985 https://doi.org/10.1016/0165-1161(85)90020-2
  21. Baik CW, Ham SS. Antimutagenic effects of browning products reacted with polyphenol oxidase extracted from apple by using SOS chromotest. Korean J. Food Sci. Technol., 22:618, 1990
  22. Miller J. : Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 1972
  23. Goldin, A, Schepartz, SA, Venditti, JM and DeVita, VT : Historical development and current strategy of the National Cancer Institute Drug Development Program. In Methods in Cancer Research, Vol. 16. Cancer Drug Development, Part A, DeVita, VT and Busch, H (eds.), Academic Press, New York, p.165, 1979
  24. Park, JG, Frucht, H, LaRocca, RV, Bliss, DP, Kurita, Y, Chen, TR, Henslee, JG, Trepel, JB, Jensen, RT, Johnson, BE, Bang, YJ, Kim, JP and Gazdar, AF Characterization of cell lines established from human gastric carcinoma. Cancer Res., 50:2773, 1990
  25. Hwang, WI, Cha, S and Lee, SY : A study on the extraction of anticancer components from Korean medicinal plants and the determination of their cytotoxic activities on the cancer cells. Korean Biochem. J., 13:25, 1980
  26. Franceschi, RT, James, WM and Zerlauth, G. : la, 25-dihydroxyvitarnin D3 specific regulation of growth, morphology and fibronectin in a human osteosarcoma cell line. J. Cellular Physiol. 123:401, 1985 https://doi.org/10.1002/jcp.1041230316
  27. Park, JG, Kramer, BS, Steinber, SM, Camichael, J, Collins, JM, Minna, JD and Gazdar, AF Chemosensitivity testing of human colorectal carcinoma cell lines using a tetrazolium-based colorimetric assay. Cancer Res., 47:5875, 1987
  28. Skehan, P, Storeng, R, Monks, SA, McMahon, J, Vistica, D, Warren, IT, Bokesch, H, Kenney, S and Boyd, MR : New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer lnst., 82:1107, 1990 https://doi.org/10.1093/jnci/82.13.1107