Immunoactivities of PVMP, a Protein-polysaccharide Fraction Isolated from Mycelial Culture of Psathyrella velutina

큰눈물버섯(Psathyrella velutina) 균사배양물로부터 분리한 단백다당체 PVMP의 면역활성

  • 정경수 (충남대학교 약학대학 미생물면역학교실) ;
  • 이지선 (충남대학교 약학대학 미생물면역학교실)
  • Published : 2004.10.01

Abstract

In the previous report, we described the marked antitumor and immunomodulatory activities of PVp, a protein-polysaccharide fraction of a Korean wild mushroom Psathyrella velutina. In this study, a protein-polysaccharide fraction, PVMP, was prepared from the shake-cultured mycelia of the same mushroom and its immunoactivities as well as chemical compositions were investigated. At 200 $\mu\textrm{g}$/ml, PVMP weakly stimulated the BALB/c mouse splenic lymphocytes to form lymphoblasts and upregulated the expression of CD25 molecules, but failed to stimulate peritoneal macrophages. In chemical analysis these two protein-polysaccharide fractions were found to be quite different in that the carbohydrate contents of PVMP and PVP, respectively, was 85.3% and 41.2%. These results reveals that PVMP, unlike PVP, is a moderate immunostimulator on the immune system.

Keywords

References

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