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The Pharmaceutical Society of Korea (대한약학회)
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An Isocoumarin with Hepatoprotective Activity in Hep G2 and Primary Hepatocytes from Agrimania pilosa

  • Park, Eun-Jeon (College of Pharmacy and Phytofermentation Research Center, Wonkwang University) ;
  • Oh, Hyun-Cheol (Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kang, Tai-Hyun (College of Pharmacy and Phytofermentation Research Center, Wonkwang University) ;
  • Sohn, Dong-Hwan (College of Pharmacy and Phytofermentation Research Center, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
  • Published : 2004.09.01
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Abstract

Phytochemical investigation of the aqueous extract of ~he roots of Agrimania pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agri-monolide (1) and agrimonolide 6-O-$\beta$-D-glucoside (3), and (＋)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC$_{50}$ values of 88.2$\pm$2.8 and 37.7$\pm$1.6 $\mu$M, respectively.y.

Keywords

References

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