한국환경과학회지 (Journal of Environmental Science International)

  • 제13권6호
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  • Pages.591-597
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  • 2004
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  • 1225-4517(pISSN)
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  • 2287-3503(eISSN)
한국환경과학회 (The Korean Environmental Sciences Society)
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E-Screen assay법을 이용한 농약화학물질의 에스트로겐 활성 연구

Study on Estrogenic Activities of Pesticide Chemicals using E-screen Assay

  • 한상국 (목포해양대학교 해양시스템공학부 해양환경공학전공)
  • 발행 : 2004.06.01
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초록

In this study, sixty chemicals including 47 pesticides were screened for estrogenic activity using E-screen assay. MCF-7 cell, used in E-screen assay, is known to be proliferated by addition of estrogenic chemicals. Eight of the measured pesticides showed estrogenic activity at the concentration range of 100-10,000nM. Their relative proliferative effect (RPE) and the relative proliferative potency (RPP) were 20-65% and 0.01-1.0%, respectively, when compared with 1.0nM of $\beta-Estradiol-17-acetate(E_{2}).$ DDVP and diazinone showed most strong estrogenic potency(RPP; 1.0%) and effect(RPE; 65%) of the eight pesticides. These results are in agreement with estrogenic activity of bisphenol A is known as a positive endocrine disrupter. Also, in this study, paraquat, DDVP, 4-chloro-3-methylphenol, 2,4,6-trichlorophenol and diazinon of the measured pesticides are estimated to estrogenic chemical.

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참고문헌

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