Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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The Study for Stability of Useful Glycyrrhiza uralensis (Licorice Root) Using Nanosolve and PMMA

Nanosolve와 PMMA를 이용한 유용성감초산의 안정화에 대한 연구

  • Published : 2004.09.01
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Abstract

Glycyrrhiza uralensis (licorice root) is very useful medicinal herb because of strong anti-inflammatory and anti-wrinkle effect. Therefore, it is widely used in functional cosmetics. However, it is insoluble and easily decomposed by light, heat, oxygen, etc. In this study, we first prepared NanoSolve-Licorice (30-50nm) using Glycyrrhiza uralensis and propylene glycol! hydrogenated lecithin/caprylic/capric triglyceride/glycerin/water system with microfluidizer. And then, NanoSolve-Licorice and porous PMMA are dispersed in ethanol. Finally, we could get a stabilized system with high-pressure homogenizer (1,000 Bar, 3 passes). According to HPLC measurement for glabridin content, our system is more stable compared with general liposome ones. Capsulated licorice has an enhanced anti-inflammatory effect on account of excellent skin penetration. We also evaluated our final product through image analyzer, particle size analyzer, FF-TEM and chromameter.

유용성 감초산은 강한 항염 작용으로 주름개선용 기능성 화장품에서 널리 사용되어지는 물질이다. 그러나 용해성이 좋지 않고 빛, 열, 산소에 의하여 변질되기 쉽다. 본 연구에서는 유용성감초산을 PG/hydrogenated lecithin/MCT/glycerine/water를 microfluidzer를 이용해 30-50nm인 nanosolve-licorice를 만들고, 잘 용해된 nanosolve-licorice를 다공성 PMMA에 에탄올과 함께 넣은 후 microfluidzer를 1000 BAR에서 연속 3회 처리하여 안정화시켰다. 이 실험에서 글라블리딘 함량을 HPLC로 측정한 결과 기존의 리포좀에 비하여 3-5배 정도 안정성을 보였으며, PMMA 캡슐로 된 리코러스는 피부의 침투가 기존 리포솜에 비하여 월등히 우수하여 항염 효과를 더욱 증가시켰다. 이러한 실험을 image analyzer, particle size analyzer, FF-TEM, chromameter, HPLC등의 분석장비를 사용하였다.

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References

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