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The Pharmaceutical Society of Korea (대한약학회)
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Protective Constituents Against Sepsis in Mice from the Root Cortex of Paeonia suffruticosa

  • Li, Gao (College of Pharmacy, Yanbian University) ;
  • Seo, Chang-Seob (College of Pharmacy, Yeungnam University) ;
  • Lee, Kyeung-Seon (College of Pharmacy, Yeungnam University) ;
  • Kim, Hyo-Jin (College of Pharmacy, Yeungnam University) ;
  • Chang, Hyun-Wook (College of Pharmacy, Yeungnam University) ;
  • Jung, Jun-Sub (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine) ;
  • Song, Dong-Keun (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine) ;
  • Son, Jong-Keun (College of Pharmacy, Yeungnam University)
  • Published : 2004.11.01
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Abstract

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.

Keywords

References

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