대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)
- 제2권1호
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- Pages.54-57
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- 2004
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
다이설피람-에탄올 반응에 의한 저체온증 1례
A case of Hypothermia Resulting from Disulfiram-Ethanol Reaction
- Bae, Hyun-A (Department of Emergency Medicine College of Medicine, Ewha Womens University) ;
- Eo, Eun-Kyung (Department of Emergency Medicine College of Medicine, Ewha Womens University)
- 발행 : 2004.06.01
초록
Disulfiram (tetraethylthiuram disulphid) is used in the treatment of chronic alcoholism since it causes an unpleasant aversive reaction to alcohol. It works by inactivating hepatic aldehyde dehydrogenase, leading to pronounced rise in the acetaldehyde concentration when ethanol is metabolized. Acetaldehyde causes alcohol sensitivity, which involve vasodilation associated with feeling of hotness and facial flushing, increased heart rate and respiration rates, lowered blood pressure, nausea, headache. One of its metabolites, diethyldithiocarbamate (DDC) can inhibit the enzyme dopamine