Korean Journal of Environmental Biology (환경생물)

Korean Society of Environmental Biology (한국환경생물학회)
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Study on the Anti - Hyperlipidemia and Liver Cell Protection of Korean Medicinal Herb Complex of Alcohol fed Rats

  • Park, Kap Joo (Department of Biological Sciences, Konkuk University) ;
  • Ahn, Ki Heung (Department of Biological Sciences, Konkuk University) ;
  • Kim, Myung Hee (Department of Foodservice & Culinary, Kyonggi University) ;
  • Lee, Hyung Hoan (Department of Biological Sciences, Konkuk University)
  • Published : 2004.12.01
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Abstract

This study sought to investigate the ameliorating effects of a Korean medicinal herb (KMH) complex on the impacts of alcohol consumption in rat hepatocytes and in reducing the total cholesterol levels and the total lipid levels in the serum. We compared the body weight gain and ratio of the liver, the kidney to body weight, and also the serum biochemistry of the rats administered with both the alcohol and the KMH complex to the control rats treated with alcohol alone. The clinically important enzyme markers (Aspartate Aminotransferase, AST, and Alanine Aminotransferase, ALT) of rats, administered with both the alcohol and the KMH complex treatments, were compared with those in the control group. The treatment regimen (KMH complex) significantly reduced the serum AST and ALT levels, indicating the hepato-protective effects of the KMH complex. Furthermore, total cholesterol and total lipid levels were significantly reduced. These results indicate that the KMH complex may positively mediate the effects of alcohol on hepatocytes and the general liver functions.

Keywords

References

  1. Baraona E and CS Lieber. 1970. Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat. J. Clin. Invest. 49:769-788 https://doi.org/10.1172/JCI106290
  2. Bode JC. 1974. in Alcohol and Aldehyde Metabolizing Systems (Eds. Thurman RG, Yonetani T, Williamson JR, and Change B). Academic Press, New York. pp.457-482
  3. Castelli WP, PW Wilson, D Levy and K Anderson. 1990. Serum Lipids and risk of coronary artery disease. AtheroscI. Rev. 21:7-10
  4. Cutta SK, PA Miller, LB Greenberg and OA Levander. 1983. Selenium and acute alcoholism. Am. J. Clin. Nutr. 38:713-718
  5. Diehl AM. 1993. Effects of alcohol on liver regeneration. Alcohol Health Res. World. 17:279-283
  6. Glueck CJ, E Hogg, C Allen and PS Gartside. 1980. Effects of alcohol ingestion on lipids and lipoproteins in normal men:isocaloric metabolic studies. Am. J. Clin. Nutr. 33: 2287-2293
  7. Gruchow HW, KA Sobocinski, JJ Barboriak and JG Scheller. 1985. Alcohol consumption, nutrient intake and relative body weight among U.S. adults. Am. J. Clin. Nutr. 42: 289-595
  8. Huh Joon. 1981. Young in Bon-Dong Eu Bo Gam. Han Sung Book Press. Seoul
  9. Karsentry BC, F Chanussot, M Ulmer and G Debry. 1985. Influence of chronic ethanol intake on obesity, liver steatosis and hyperlipidaemia in the Zucker fa/fa rat. Br. J. Nutr. 54:5-13 https://doi.org/10.1079/BJN19850086
  10. Kien CL and HE Ganther. 1983. Manifestations of chronic selenium deficiency in a child receiving total parenteral nutrition. Am. J. Clin. Nutr. 37:319-328
  11. Kovanen PT and WJ Scheider. Regulation of the Low-density Lipoprotein (B/E) Receptor. 1999. Adv. Vase. BioI. 5: 165-185
  12. Levy RI, M Bonnell and ND Ernst. 1976. Dietary management ofhyperlipoproteinemia. J. Am. Dietar. Assoc. 58: 406-417
  13. Lieber C S. 1995. Medical disorders of alcoholism. N. EngI. J. Med. 333:1058-1065 https://doi.org/10.1056/NEJM199510193331607
  14. Lieber CS. 2001. Alcoholic liver injury:pathogenesis and therapy in 2001. PathoI. BioI. 49:738-752 https://doi.org/10.1016/S0369-8114(01)00239-5
  15. Liu GT. 1989. Pharmacological actions and clinical use of Fructus schizandrae. Chin. Med. J. (Engl). 22: 740-749
  16. Maher JJ. 1997. Exploring alcohol's effects on liver function. Alcohol Health Res. World. 21:5-12
  17. Murray CJL and AD Lopez. 1996. 'The global burden of disease'. Oxford University Press, London
  18. Park KJ, MJ Lee, H Kang, KS Kim, SH Lee, IH Cho and HH Lee. 2002. Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol. BioI. Pharm. Bull. 25:1451-1455 https://doi.org/10.1248/bpb.25.1451
  19. Piola RC and CS Lieber. 1975. Energy wastage in rats given drugs that induce microsomal enzymes. J. Nutr. 105:1544-1548
  20. Potter SM. 1995. Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J. Nutr. 123:606-611
  21. Rahimtoola SH. 1985. Cholesterol and coronary heart disease. J. Am. Med. Assoc. 253:2094-2095 https://doi.org/10.1001/jama.253.14.2094
  22. Thompson IN and ML Scott. 1970. Impaired lipid and vitamin E absorption related to atrophy of the pancreas in selenium-deficient chicks. J. Nutr. 100:797-809
  23. Tsukamoto H, K Gaal and SW French. 1990. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12:599-608 https://doi.org/10.1002/hep.1840120325
  24. Tsukamoto H, SJ Towner, LM Ciofalo and SW French. 1986. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6:814-822 https://doi.org/10.1002/hep.1840060503