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The Pharmaceutical Society of Korea (대한약학회)
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Determination of Stability Constants of the Inclusion Complexes of ${\beta}$-Blockers in Heptakis (2,3-Dimethyl-6-Sulfato)- ${\beta}$-Cyclodextrin

  • Phuong, Nuyen Thi (College of Pharmacy, Chungnam National University) ;
  • Lee, Kyung-Ah (College of Pharmacy, Chungnam National University) ;
  • Kim, Kyung-Ho (College of Pharmacy, Kangwon National University) ;
  • Choi, Jung-Kap (College of Pharmacy, Chonnam National University) ;
  • Kim, Jong-Moon (Central Research Institute, Ilsung Pharmaceutical Co.) ;
  • Kang , Jong-Seong (College of Pharmacy, Chungnam National University)
  • Published : 2004.01.01
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Abstract

The ${\beta}$-blockers possess at least one chiral center and the S(-)-enantiomer shows higher affinity for binding to the ${\beta}$-adrenergic receptors than antipode. The stability constants of acebutolol, celiprolol, propranolol and terbutaline in the inclusion complexes with single-isomer heptakis (2,3-dimethyl-6-sulfato)- ${\beta}$-cyclodextrin (HDMS-${\beta}$-CD) were determined by capillary electrophoresis. The approximation and linear double reciprocal methods were adapted with comparable results. Among the ${\beta}$-blockers studied, propranolol had the lowest stability constant but the highest enantioselectivity, indicating that the magnitudes of the stability constants carried little information about enantioseparation. The magnitudes of enantioselectivities between the enantiomer pair were in the order of propranolol > celiprolol > terbutaline > acebutolol.

Keywords

References

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