Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana Water Extracts on Plasma Biomarkers in Streptozotocin - Induced Diabetic Rats

두릅, 오가피 및 느릅 열수추출물이 Streptozotocin 투여 흰쥐의 혈장바이오마커에 미치는 영향

  • Shin, Kyong-Hee (Dept. of Food and Nutrition, Yeungnam University) ;
  • Cho, Soo-Yeul (Dept. of Food and Nutrition, Yeungnam University) ;
  • Lee, Mi-Kyung (Food and Bio-Industry Research Institute, Kyongbuk National University) ;
  • Lee, Jeong-Sook (Dept. of Food and Nutrition, Kosin University) ;
  • Kim, Myung-Joo (Dept. of Food Science and Nutrition, Daegu Polytechnic College)
  • 신경희 (영남대학교 식품영양학과) ;
  • 조수열 (영남대학교 식품영양학과) ;
  • 이미경 (경북대학교 식품생물산업연구소) ;
  • 이정숙 (고신대학교 식품영양학과) ;
  • 김명주 (대구산업정보대학 식품영양과)
  • Published : 2004.11.01
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Abstract

This study was conducted to investigate the effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts on plasma glucose and biomarkers in the streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into normal and diabetic groups. The diabetic groups subdivided into the control group (DM), Aralia elata (DM-AE), Acanthopanacis cortex (DM-AC) and Ulmus davidiana (DM-UD). The extracts were supplemented in diet base on 11.42 g of raw materials/㎏ diet for 7 weeks. The diabetes was induced by injecting STZ (55 ㎎/㎏ B.W., i.p.) once 2 weeks before sacrifying. Plasma glucose level was significantly higher in the DM group than in the normal group, whereas insulin and C-peptide concentrations were significantly lowered in the DM groups compared to the normal group. These parameters were normalized in the DM-AE, DM-AC and DM-UD supplemented groups. Plasma albumin content was significantly lowered in the DM group compared to the normal group, yet it was significantly higher in the DM-AE group than in the DM group. Bilirubin and creatinine contents were elevated in the DM group, while the supplementation of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts ameliorate the change of these contents in STZ-induced diabetic rats. Plasma AST, ALT, ALP and LDH activities were significantly higher in the DM group than in the normal groups. The supplementation of Araliaceae family water extracts significantly lowered these parameters compared to the DM group. Accordingly, these results indicate that Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts would seem to improve the glucose and biomarker in STZ-induced diabetic rats.

Wistar계 흰쥐에게 두릅, 오가피 및 느릅의 열수추출물을 급여하여 7주간 급여하였으며 희생 2주전에 STZ으로 당뇨를 유발하여 혈당이 300 ㎎/dL 이상인 흰쥐를 대상으로 혈장 중의 포도당 농도 및 바이오마커에 미치는 영향을 구명하였다. 혈장의 포도당 함량은 두릅나무과 식물의 열수추출물 급여시 대조군에 비해 유의적인 혈당저하 효과가 관찰되었으며, 혈장의 인슐린과 C-펩타이드 함량 역시 두릅, 오가피 및 느릅 열수추출물 급여시 STZ 투여에 의한 변화가 완화되었다. 혈장 중의 알부민 함량은 당뇨대조군이 정상군에 비하여 유의적으로 감소되었으며 실험식이 급여시 증가되는 경향이었다. 빌리루빈과 크레아티닌 함량은 STZ 투여로 유의적으로 증가되었으나 실험식이를 급여한 모든 군에서 유의적으로 감소되었다. 두릅, 오가피 및 느릅 열수추출물은 당뇨 유발로 증가된 혈장의 AST, ALT, ALP 및 LDH의 활성을 유의적으로 억제하였다. 따라서 두릅나무과 식물 중 두릅, 오가피 및 느릅의 열수추출물은 STZ 투여 흰쥐의 혈당강하 및 혈장바이오마커의 변화 개선에 효과적인 것으로 관찰되었다.

Keywords

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