Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Mechanism Study of Cheonmabanhwa-Tang on the Cerebral Ischemia in Rats - Focusing arround Improvement in Changes of Cerebral Hemodynamics -

천마반하탕이 뇌허혈에 미치는 기전 연구

  • Yang Gi Ho (College of Oriental Medicine, Dongshin University) ;
  • Lee Geum Soo (College of Oriental Medicine, Dongshin University) ;
  • Kim Young Kun (College of Oriental Medicine, Dongshin University) ;
  • Jeong Hyun Woo (College of Oriental Medicine, Dongshin University) ;
  • Kim Gye Yeop (College of Oriental Medicine, Dongshin University) ;
  • Jeon Byung Gwan (Department of Environmental Engineering, Dongshin University) ;
  • Lee Won Suk (Department of Phamachology, College of Medicine, Busan University)
  • 양기호 (동신대학교 한의과대학) ;
  • 이금수 (동신대학교 한의과대학) ;
  • 김영근 (동신대학교 한의과대학) ;
  • 정현우 (동신대학교 한의과대학) ;
  • 김계엽 (동신대학교 한의과대학) ;
  • 전병관 (동신대학교 공과대학 환경공학과) ;
  • 이원석 (부산대학교 의과대학 약리학교실)
  • Published : 2004.10.01
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Abstract

Cheonmabanhwa-Tang(CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. This Study was designed to investigate the mechanism of Prescription on cerebral hemodynamics [regional cerebral blood flow(rCBF) and pial arterial diameter(PAD)J in cerebral ischemia rats, The results in cerebral ischemic rats were as follows: Both rCBF and PAD were significantly and stably increased by CBT (10 ㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. Pretreatment with indomethacin(1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase significantly but unstably increased the CBT-induced increases in PAD as well as rCBF during the period of cerebral reperfusion. Pretreatment with methylene blue(10 (.1.㎍/㎏, i.p.), an inhibitor of guanylate cyclase significantly but unstably increased the CBT-induced increases in PAD as well as rCBF during 150 minutes of cerebral reperfusion, but decreased stably the CBT-induced increases in rCBF and PAD after 180 minutes of cerebral reperfusion. In conclusion, the present authors thought that CBT caused effect on cerebral hemodynamics via mediation of cyclooxygenase.

Keywords

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