Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Recent Studies of the Effects of Herbal Medicines on Angiogenesis

한약물을 이용한 혈관신생 촉진에 대한 최근의 연구동향

  • Lee, Song-shil (Oriental Medicine Research Center for Bone & Joint Disease, KyungHee University) ;
  • Kang, Jung-won (Dept. of Acupuncture & Moxibustion, College of Oriental Medical, KyungHee University) ;
  • Back, Yong-hyeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medical, KyungHee University) ;
  • Choi, Do-young (Dept. of Acupuncture & Moxibustion, College of Oriental Medical, KyungHee University) ;
  • Park, Dong-seok (Dept. of Acupuncture & Moxibustion, College of Oriental Medical, KyungHee University) ;
  • Kim, Deog-yoon (Dept. of Nuclear Medicine, College of Oriental Medical, KyungHee University) ;
  • Kim, Kang-il (Dept. of Orthopedic Surgery, College of Medicine, KyungHee University) ;
  • Park, Sang-do (Division of Rheumatology, Dept. of Internal Medicine, College of Medicine, KyungHee University) ;
  • Yang, Ha-ru (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ji, Mi-young (Oriental Medicine Research Center for Bone & Joint Disease, KyungHee University) ;
  • Lee, Jae-dong (Dept. of Acupuncture & Moxibustion, College of Oriental Medical, KyungHee University)
  • 이송실 (경희대학교 골관절질환 한방연구센터) ;
  • 강중원 (경희대학교 한의과대학 침구과) ;
  • 백용현 (경희대학교 한의과대학 침구과) ;
  • 최도영 (경희대학교 한의과대학 침구과) ;
  • 박동석 (경희대학교 한의과대학 침구과) ;
  • 김덕윤 (경희대학교 의과대학 핵의학과) ;
  • 김강일 (경희대학교 의과대학 정형외과) ;
  • 박상도 (경희대학교 의과대학 류마티스내과) ;
  • 양하루 (한국한의학연구원 한약제제연구부) ;
  • 지미영 (경희대학교 골관절질환 한방연구센터) ;
  • 이제동 (경희대학교 한의과대학 침구과)
  • Received : 2004.05.14
  • Accepted : 2004.05.15
  • Published : 2004.06.20
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Abstract

Background : Angiogenesis is the proliferation of a network of blood vessels emanating from pre-existing vessels, supplying nutrients and oxygen and removing waste products. Angiogenesis occurs in a variety of normal physiologic and pathologic conditions and is regulated by a balance of stimulatory and inhibitory angiogenic factors. Excessive angiogenesis should be suppressed. However, if blood supply is insufficient, it should be encouraged. Hyul-Mek(血脈) or Hyul-Rark(血絡), known as blood vessels in western medicine, is deeply related to Chung-Ki-Hyul(精 氣 血). The goal of this study is to review the effects of herbal medicines on angiogenesis that is involved in wound healing and enhancement of blood supply. Methods : We conducted a systematic and comprehensive literature search for the identification, retrieval, and bibliographic management of independent studies to locate information on the topic. A computerized search of the published literature of Korea(KISS, RISS), China(CNKI), Japan(Kampo medicine, etc), and western countries(MEDLINE) was performed, and further supplemented with manual searches of print sources(1999 to 2003). Results : The herbal medicines with angiogenic activity were mainly found among herbs that carry replenish Shin-Cheng(補腎益精), foster Eum and improve the circulation of blood(養陰活血), or warm and circulate Kyung-Rark(溫經通絡). In particular, herbs with improve the circulation of blood and clear blood(活血化瘀) activity contain a significant amount of tannin, saponin, and pyrazine. Conclusion : Replenish Ki-Hyul(補氣血) and circulate Kyung-Rark(通經絡) could contribute to the induction of angiogenesis because various growth factors and proliferation, differentiation, and migration of vascular endothelial cells are involved in angiogenic activity.

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Acknowledgement

Supported by : 보건복지부