Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Cytotoxic Constituents of the Octocoral Dendronephthya gigantea

  • Han Ah Reum (College of Pharmacy, Ewha Womans University) ;
  • Song Jun Im (College of Natural Science, Ewha Womens University) ;
  • Jang Dae Sik (Department of Herbal Parmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Min Hye Young (College of Pharmacy, Ewha Womans University) ;
  • Lee Sang Kook (College of Pharmacy, Ewha Womans University) ;
  • Seo Eun Kyoung (College of Pharmacy, Ewha Womans University)
  • Published : 2005.03.01
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Abstract

A known monoalkyl glycerol ether, ($\pm$)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (28,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1 ,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

Keywords

References

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