Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Genistein and Soy Protein on Lipids Metabolism in Ovariectomized Rats

난소절제 랫드에서 제니스테인과 콩단백질이 지질 대사에 미치는 영향

  • Lee Young Min (Division of Metabolic Disease, Department of Biomedical Sciences, National Institute of Health, Department of Food and Nutrition, Seoul National University) ;
  • Jung Myeong Ho (Division of Metabolic Disease, Department of Biomedical Sciences, National Institute of Health) ;
  • Lee Yeon Sook (Department of Food and Nutrition, Seoul National University) ;
  • Song Jihyun (Division of Metabolic Disease, Department of Biomedical Sciences, National Institute of Health)
  • 이영민 (질병관리본부 국립보건연구원 생명의학부 대사영양질환과, 서울대학교 식품영양학과) ;
  • 정명호 (질병관리본부 국립보건연구원 생명의학부 대사영양질환과) ;
  • 이연숙 (서울대학교 식품영양학과) ;
  • 송지현 (질병관리본부 국립보건연구원 생명의학부 대사영양질환과)
  • Published : 2005.05.01
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Abstract

Postmenopausal women or ovariectomized rats are associated with increased cholesterol levels, which are risk factors of metabolic syndrome and cardiovascular diseases. Increased prevalence of metabolic syndrome after menopause might be associated with estradiol deficiency. Harmful effect of estradiol hampers the casual usage of hormone to prevent the metabolic syndrome. Soy protein has been reported to show several beneficial effects on health, however it is unclear which components of soy protein is responsible for anti-obesity and hypocholesterolemic effects. Soy isoflavones, gem-stein and daizein, are suggested to have anti-obesity and hypocholesterolemic effects but with inconsistency. The present study investigated the effect of supplementation of genistein (experiment I) and soy protein containing isoflavones (experiment II) to high fat diet on body weight gain, food intake, liver and fat tissue weight and the lipid levels in ovariectomized rats. Plasma and hepatic lipid contents and the mRNA levels of genes encoding lipid metabolism related proteins, such as CPT1 and HMGR were measured. Ovariectomy increased body weight, fat tissue weight and plasma and hepatic lipid levels which increase the risk of metabolic syndrome. Soy protein could improve plasma and hepatic lipids levels. Soy protein also increased hepatic CPT1 and HMGR mRNA levels. Plasma and hepatic lipids levels could not be decreased by dietary genistein alone. In contrast, lipids levels could be decreased by isoflavone-fortified soy protein, suggesting that the ingestion of soy protein enriched with isoflavone gives more benefit for protecting postmenopausal women from metabolic syndrome.

Keywords

References

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