Transactions of the Korean Society of Mechanical Engineers A (대한기계학회논문집A)

The Korean Society of Mechanical Engineers (대한기계학회)
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The Effect of Milling Time and Speed on the Particle Size of Ibuprofen in the Cryogenic Ball Milling Process

극저온 볼 밀링 공정시 밀링시간 및 속도가 Ibuprofen분말의 입자 크기에 미치는 영향

  • Published : 2005.07.01
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Abstract

In this study, ball milling process was applied to reduce the particle size of bio-material down to submicron size. The material used was Ibuprofen. The ball milling was performed at low temperature of about $-180^{\circ}C$. The effect of processing conditions (milling time, milling speed) on the particle size was determined. The results showed that the degree of crystallite of Ibuprofen was slightly reduced by the ball milling process. The results also showed that the size of Ibuprofen was significantly reduced by the ball milling process. The effect of milling time was significant within the milling time of six hours while it was small thereafter.

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References

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  1. Optimization of Process Variables for Grinding of Ibuprofen using Response Surface Methodology vol.51, pp.6, 2013, https://doi.org/10.9713/kcer.2013.51.6.685