Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Pleurotus eryngii on Lipid Metabolism in Rats Fed High Fat Diet

새송이버섯이 고지방 식이를 급여한 흰쥐의 지질대사에 미치는 영향

  • 고진복 (신라대학교 생명과학과) ;
  • 이충언 (신라대학교 생명과학과)
  • Published : 2005.06.01
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Abstract

The effects of Pleurotus (P.) eryngii on the weight gains, food efficiency ratios, serum and hepatic lipid concentrations were investigated in male rats fed the high fat diets. Twenty one week-old Sprague-Dawley rats were given three different types of diet for 10 weeks, respectively: a control diet (high fat; $20\%$ lard), two kinds of P. eryngii diet supplemented with $3\%\;or\;5\%$ of dry P. eryngii powder in substitutes for the same amounts of cellulose in the control diets. The body weight gains and food efficiency ratios of the rats fed $3\%\;and\;5\%$ P. eryngii diets were significantly lower than those of the rats fed the control diet. The concentrations of hepatic total lipid and triglyceride in the rats fed the P. eryngii diets were significantly lower than those in the rats fed the control diet. But the hepatic cholesterol contents of the rats fed the P. eryngii diets were similar to those of the rats fed the control diet. The concentrations in serum total cholesterol, LDL-cholesterol, and atherogenic index ratios were significantly lower in the rats fed the P. eryngii diets compared to those fed the control diet. The HDL-cholesterol/total- cholesterol ratio was significantly higher in the rats fed the P. eryngii diets compared to those fed the control diet. There were no significant difference found in the serum triglyceride, phospholipid and HDL-cholesterol concentrations among the experimental groups. These results showed that feeding of P. eryngii powder feeding decreased the total cholesterol, LDL-cholesterol and atherogenic index and increased the HDL-cholesterol/total-cholesterol ratio in serum of the rats fed high fat diet.

새송이버섯이 고지방식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 성숙한(생후 21주령) 숫쥐에 표준식 이에 $20\%$ 돈지를 첨가한 식이를 급여한 대조군, 대조식이에 새송이 버섯 분말을 $3\%$ 및 $5\%$씩 첨가한 식이를 급여한 군($3\%$ 및 $5\%$ 새송이버섯군) 등 3군으로 나누어 10주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량 및 식이효율은 대조군에 비하여 $3\%$ 및 $5\%$ 새송이버섯군이 유의하게 감소되었다. 간과 신장 및 부고환지방의 무게는 대조군과 새송이버섯군들이 비슷하였다. 간의 총 지질 및 중성지질 농도는 대조군에 비하여 새송이버섯군들이 유의하게 감소 되었다. 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 새송이 버섯군들이 유의하게 감소되었다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 새송이버섯군들이 유의하게 증가되었다. 변의 g당 총 지질배설량은 새송이버섯군이 대조군보다 유의하게 증가된 것으로 나타났다. 이상의 결과로 보아 고지방식이에 새송이버섯 분말 첨가 급여시 흰쥐 간의 중성지질 농도, 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 것으로 나타났다.

Keywords

References

  1. Manzi P, Marconi S, Aguzzi A, Pizzoferrato L. 2004. Commercial mushrooms: nutritional Quality and effect of cooking. Food Chemistry 84: 201-206 https://doi.org/10.1016/S0308-8146(03)00202-4
  2. Guillen F, Munoz C, Gomez-Toribio V, Martinez AT, Martinez MJ. 2000. Oxygen activation during oxidation of methoxyhydroquinones by laccase from Pleurotus eryngii. Appl Environ Microbiol 66: 170-175 https://doi.org/10.1128/AEM.66.1.170-175.2000
  3. Kang TS, Kang MS, Lee SY. 2001. Effect of Pleurotus eryngii on the blood glucose and cholesterol in diabetic rats. Korean J Mycology 29: 86-90
  4. Hwang YJ, Nam HK, Kim SH. 2003. Effeect of Lentinus edodes and Pleurotus eryngii extracts on proliferation and apoptosis in human colon cancer cell lines. J Korean Soc Food Sci Nutr 31: 217-222
  5. Kim JY, Kang Hl, Seo Kl. 2004. Antioxidative and antitumor activities of crude polysaccaride fraction Pleurotus eryngii. J Korean Soc Food Sci Nutr 33: 1589-1593 https://doi.org/10.3746/jkfn.2004.33.10.1589
  6. Bobek P, Ozdin L, Kuniak L. 1997. Effect of oyster mushroom and isolated $\beta$-glucan on lipid peroxidation and on the activities of antioxidative enzymes in rats fed the cholesterol diet. J Nutr Biochem 8: 469-489 https://doi.org/10.1016/S0955-2863(97)00058-2
  7. Bobek P, Ozdin L, Galbavy S. 1998. Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pteurotus ostreatus) in rats. Nutrition 14: 282-286 https://doi.org/10.1016/S0899-9007(97)00471-1
  8. Filipel J. 1992. The effect of the mushroom Pleurotus ostreatus on the lipid peroxidation of phosphatidylcholine liposomes. Pharmazie 47: 393-398
  9. Pella D, Rybar R. 1997. Pleurotus ostreatus-effective hypolipidaemic agent. Atherosclerosis 134: 332-338
  10. Koh JB, Choi MA. 2001. Effect of Cordyceps militaris on lipid metabolism in rats fed cholesterol diet. Korean J Nutr 34: 265-270
  11. Koh JB. 2002. Effect of Cordyceps militaris on lipid metabolism, protein levels and enzyme activities in rats fed high fat diet. Korean J Nutr 35: 414-420
  12. Koh JB, Choi MA. 2003. Effect of Paecilomyes japonica on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 32: 238-243 https://doi.org/10.3746/jkfn.2003.32.2.238
  13. Lee HJ, Koh JB. 2003. Effects of liquid culture of Agaricus blazei Murill on lipid metabolism and enzyme activities in rats fed high fat diet. Korean J Nutr 36: 352-358
  14. Oh SW, Lee CU, Koh JB. 2004. Effects of Agaricus blazei Murill on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 33: 821-826 https://doi.org/10.3746/jkfn.2004.33.5.821
  15. Cheung PCK. 1996. The hypocholesterolemic effect of extracellular polysaccharide from the submerged fermentation of mushroom. Nutr Res 16: 1953-1957 https://doi.org/10.1016/S0271-5317(96)00218-7
  16. AOAC. 1980. Official methods of analysis. 15th ed. Association of official analytical chemists, Washington DC. p 211-260
  17. Reeves PG, Nielsen FH, Fahey GC. 1993. AIN-93 purified diets for laboratory rodents final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951 https://doi.org/10.1093/jn/123.11.1939
  18. Cheung PCK. 1998. Plasma and hepatic cholesterol levels and fecal neutral sterol excretion are altered in hamsters fed straw mushroom diets. J Nutr 128: 1512-1516
  19. Haglund O, Loustarinen R, Wallin R, Wibell I, Saldeen T. 1991. The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin. Eur J Nutr 121: 165-172 https://doi.org/10.1093/jn/121.2.165
  20. Folch J, Lees M, Stanley GSH. 1957. A simple method for the isolation and purification of total lipid from animal tissues. J Biol Chem 226: 497-509
  21. Frings CS, Dunn RT. 1970. A colorimetric method for determination of total serum lipid based on the sulfophospho-vanillin reaction. Am J Clin Path 53: 89-91 https://doi.org/10.1093/ajcp/53.1.89
  22. Anderson JW, Bryant CA. 1986. Dietary fiber: Diabetes and obesity. Am J Gastroenterol 81: 898-905
  23. Choi MY, Lim SS, Chung TY. 2000. The effects of hot water soluble polysaccharides from Lentinus edodes on lipid metabolism in the rats fed butter yellow. J Korean Soc Food Sci Nutr 29: 294-299
  24. Sugiyama K, Saeki S, Ishiguro Y. 1992. Hypercholesterolemic activity of ningyotake (Poyporus corfluens) mushroom in rats. J Jpn Soc Nutr Food Sci 45: 265-270 https://doi.org/10.4327/jsnfs.45.265
  25. Koh JB. 2003. Effect of liquid cultures of Cordyceps militaris on lipid metabolism and enzyme activities in hyperlipidemic female rats. Korean J Life Sci 13: 265-272 https://doi.org/10.5352/JLS.2003.13.3.265
  26. Kabir Y, Kimura S, Tamura T. 1988. Dietary effects of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypotensive rats (SHR). J Nutr Sci Vitaminol 34: 433-438 https://doi.org/10.3177/jnsv.34.433
  27. Kim BK, Shin GG, Jeon BS, Cha JY. 2001. Cholesterollowering effect of mushrooms powder in hyperlipidemic rats. J Korean Soc Food Sci Nutr 30: 510-515
  28. Ebihara K, Schnceman BO. 1989. Interaction of bile acids, phospholipids, cholesterol and triglycerides with dietary fiber in the small intestine of rats. J Nutr 119: 1100-1106 https://doi.org/10.1093/jn/119.8.1100
  29. Cheung PCK. 1996. The hyporcholesterolemic effect of two edible mushrooms: Auricularia aurivula (tree-ear) and Tremellafuciformis (white jelly-leaf) in hypercholesterolemic rats. Nutr Res 16: 1721-1725 https://doi.org/10.1016/0271-5317(96)00191-1
  30. Manzi P, Gambelli L, Marconi S, Vivanti V, Pizzoferrato L. 1999. Nutrients in edible mushrooms: an inter-species comparative study. Food Chemistry 65: 477-482 https://doi.org/10.1016/S0308-8146(98)00212-X
  31. Kinosian B, Glick H, Preiss L, Puder KI. 1995. Cholesterol and coronary heart disease: predicting risk in men by changes in levels and ratios. J Invest Med 43: 443-450
  32. Kailash P. 1999. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99: 1355-1362 https://doi.org/10.1161/01.CIR.99.10.1355

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