Effect of Organic Sulfur-Containing Compounds on Hepatotoxicity in Rats Induced by N, N-Dimethylnitrosamine

디메틸니트로자민에 의한 흰쥐의 간독성에 미치는 유기황화합물의 효과

  • Shin Hea Soon (College of Pharmacy, Duksung Women's University) ;
  • Kang Joo Yeon (College of Pharmacy, Duksung Women's University)
  • 신혜순 (덕성 여자대학교 약학대학) ;
  • 강주연 (덕성 여자대학교 약학대학)
  • Published : 2005.09.01

Abstract

This study il focused on the hepatopreventive effect in cirrhotic rats induced by N, N -dimethylnitrosamine treatment when organir Lulfur -containing compoundE were orally injected. Biochemical parameters (aspatate transaminase (AST), alanine transaminase (ALT) alkaline phosphatase (ALP), 1-protein and t-bilirubin) were measured in serum injured liver tissue. The increased AST and ALT values were significantly reduced by organic sulfur-containing compounds at the oral dotes of 50 mg/kg. The result of morphological changes have illustrated the accumulation of liver damages, Each as inflammatory cell accumulation and cirrhosis, caused by N, N-dimethylnitrosamine. Also, it was found that liver damages were prevented by the treatment of organic sulfur- containing compounds.

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