Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
권호 표지

Preparation and Swelling Characteristics of Hydrogel from Microbial Poly(${\gamma}-glutamic acid$) by ${\gamma}$-Irradiation

  • Choi, Seong-Hyun (The Institute of Natural Science, Mokwon University) ;
  • Whang, Kyung-Sook (Division of Lifescience, Mokwon University) ;
  • Park, Jong-Soo (Namyang Dairy Products Co., Ltd.) ;
  • Choi, Woo-Young (Department of Agricultural Chemistry, College of Agriculture and Lifesciences, Chungnam National University) ;
  • Yoon, Min-Ho (Department of Agricultural Chemistry, College of Agriculture and Lifesciences, Chungnam National University)
  • Published : 2005.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Microbial hydrogel was prepared by ${\gamma}-irradiation$ of poly(${\gamma}-glutamic acid$) (PGA) which was produced from Bacillus subtilis BS 62 and it's physico-chemical characteristic was examined. The hydrogel, prepared from 10% PGA with the dose of 48 kGy, was swollen up to 1,370 times of specific water content as dry weight basis. The hydrogels obtained above the dose of 48 kGy appeared to have higher compressive strength but lower specific water content. The period to reach a swelling equilibrium for the hydrogel in deionized water at the temperature range of 4 to $45^{\circ}C$ was about 10 h. The swollen hydrogel was shrunk in ionic solutions with the increase of ionic strength, and the rate of shrinkage was greater in calcium chloride solution than in sodium chloride. Specific water content of the hydrogel was quickly decreased at $80^{\circ}C$, showing a thennally hydrodegradable property.

Keywords

References

  1. H. J. Choi and M. Kunioka, Radiat. Phys. Chem., 46, 175 (1995) https://doi.org/10.1016/0969-806X(95)00308-K
  2. V. Lenaert and R. Gurny, in Bioadhesive Drug Delivery Systems, Boca raton (FL), CRC Press, 1990, pp 1-24
  3. C. A. Scotchford, M. G. Cascone, S. Downes, and P. Giusti, Biomaterials, 19, 1 (1998) https://doi.org/10.1016/S0142-9612(97)00236-6
  4. R. Kishi, H. Ichijo, and O. Hirasa, J. Intell. Mater. Syst. Struct., 4, 533 (1993) https://doi.org/10.1177/1045389X9300400413
  5. N. A. Peppas and E. W. Merrill, J. Polym. Sci., 14, 441 (1976)
  6. A. S. Hoffman, J. Control. Release, 6, 297 (1987) https://doi.org/10.1016/0168-3659(87)90083-6
  7. J. H. Wardand and N. A. Peppas, J. Control. Release, 71, 183 (2001) https://doi.org/10.1016/S0168-3659(01)00215-2
  8. K. R. Kamathand and K. Park, Adv. Drug Delivery Rev., 11, 59 (1993) https://doi.org/10.1016/0169-409X(93)90027-2
  9. M. Kunioka and H. J. Choi, Polym. Degrad. Stab., 59, 33 (1998) https://doi.org/10.1016/S0141-3910(97)00181-X
  10. S. H. Choi, J. S. Park, K. S. Whang, M. H. Yoon, and W. Y. Choi, Agric. Chem. Biotechnol., 47, 60 (2004)
  11. T. Hara, A. Shiraishi, H. Fujii, and S. Ueda, Agric. Biol. Chem., 48, 2373 (1984) https://doi.org/10.1271/bbb1961.48.2373
  12. T. Hara, S. H. Choi, and W. Y. Choi, J. Microbiol. Biotechnol., 11, 342 (2001)
  13. J. Ricka and T. Tanaka, Macromolecules, 17, 2916 (1984) https://doi.org/10.1021/ma00142a081
  14. P. Markland, G. L. Amidon, and V. C. Yang, Intern. J. Pharmaceutics, 178, 183 (1999) https://doi.org/10.1016/S0378-5173(98)00373-1
  15. H. J. Choi, in Characterization of Hydrogel Prepared by $\gamma$- irradiation from Microbial Poly($\gamma$-glutamic acid), Ph.D thesis in the graduate school, Yonsei University, Korea, 1996
  16. K. Fan, D. Gonzales, and M. Sevoian, J. Environ. Polym. Degrad., 4, 253 (1996) https://doi.org/10.1007/BF02070694