Effect of Juglandis Semen Herbal Acupuncture on Rat by Glycerol-Induced Acute Renal Failure

호도약침(胡桃藥鍼)이 Glycerol로 유발(誘發)된 급성신부전(急性腎不全) 백서(白鼠)에 미치는 영향(影響)

  • Jung, Hyun-Chol (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University) ;
  • Kim, Cheol-Hong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Youn, Hyoun-Min (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Jang, kyung-Jeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Ahn, Chang-Beohm (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University)
  • 정현철 (동의대학교 한의과대학 경혈학교실) ;
  • 김철홍 (동의대학교 한의과대학 침구학교실) ;
  • 윤현민 (동의대학교 한의과대학 침구학교실) ;
  • 장경전 (동의대학교 한의과대학 침구학교실) ;
  • 안창범 (동의대학교 한의과대학 침구학교실) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실)
  • Published : 2005.09.27

Abstract

Objective : This study was undertaken to determine if Juglandis Semen herbal acupuncture(Ja) has a protective effect against glycerol-induced acute renal failure in rats. Methods : Rats were dehydrated for 24hr and then injected with 5 ml/kg of 50 % glycerol, one-half of dose in each hindlimb muscle. In experiments for Ja effect, rats received 0.1 ml of Ja extraction in both sides of corresponding $Sh\grave{e}nsh\bar{u}(BL_{23})$ of human body and non-acupuncture points(the root of tail) for 3 days after injection of glycerol. The experimental group were divided into the Normal group, the Control group, the Ja to $Sh\grave{e}nsh\bar{u}(BL_{23})$ group(Ja-AS), the Ja to non-acupuncture points group(Ja-AN). Results : There were significant decrease of urine volume, BUN, fractional glucose excretion, fractional phosphate excretion, total protein level in Ja-AS as compared with the control group. Conclusion : This suggests that Ja-AS could be used in prevention and treatment of acute renal failure. However, the precise mechanisms of Ja protection remain to be determined.

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