Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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The Effect of Plantaginis Semen Herbal Acupuncture on Acute Renal Failure in Rat

차전자약침(車前子藥鍼)이 급성신부전(急性腎不全) 백서(白鼠)에 미치는 영향(影響)

  • Cho, Si-Yong (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University) ;
  • Kim, Cheol-Hong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Youn, Hyoun-Min (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Jang, Kyung-Jeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Ahn, Chang-Beohm (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University)
  • 조시용 (동의대학교 한의과대학 경혈학교실) ;
  • 김철홍 (동의대학교 한의과대학 침구학교실) ;
  • 윤현민 (동의대학교 한의과대학 침구학교실) ;
  • 장경전 (동의대학교 한의과대학 침구학교실) ;
  • 안창범 (동의대학교 한의과대학 침구학교실) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실)
  • Published : 2005.12.27
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Abstract

Objective : This study was undertaken to determine if Plantaginis Semen herbal acupuncture(PSA) has a protective effect on glycerol-induced acute renal failure in rats. Methods : Rats were dehydrated for 24hr and then injected with 4 ml/kg of 50% glycerol in each hindlimb muscle. In experiments for PSA effect, rats were received 0.1 ml of PSA extraction in both sides of corresponding $Sh\grave{e}nsh\bar{u}(BL_{23})$ of human body for 3 days after injection of glycerol. The experimental group were divided into the normal group, the control group, the sample 1,2,3 group. Results : Glycerol injection decreased glomerular filtration rate and increased urine volume, serum creatinine, BUN level and fractional excretion of $Na^+,\;K^+\;and\;Cl^-$. These results show that glycerol injection bring about acute renal failure. PSA significantly increased glomerular filtration rate and significantly decreased serum creatinine, BUN level and fractional excretion of $Na^+,\;and\;Cl^-$ as compared with control group. Conclusion : These results suggest that PSA can be used in prevention and treatment for acute renal failure. However, the precise mechanisms of PSA protection remain to be determined.

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